医学遗传学是探讨遗传因素相关疾病的诊断、预防与治疗的基础医学类课程，本门课要求学生具备较强的逻辑思维，有独立思考和分析解决问题的能力。单一的“填鸭式”课堂教学很难调动学生的自主学习，无法达到医学遗传学的教学效果。案例研讨式教学打破了被动的传统教学模式，教师给出临床典型案例，学生围绕案例的相关问题准备材料，主动展开课堂讨论，以教与学互动的方式融汇贯通了本门课程的重点与难点，教学效果显著。自2013年起，本教研组针对临床医学本科生开展了案例研讨式教学。本文根据课程的教学计划和案例研讨式教学的实际情况，筛选并分类整理了所收集的临床案例资料，分章节归纳汇编了8个章节的教学案例库，基本涵盖了疾病遗传学与临床遗传学的教学重难点。医学遗传学教学案例库的建设实现了临床案例与教学的深度融合，学生以更为直观的方式理解掌握教学重难点，有助于激发学生的创新思维，提高学生的学习兴趣与课堂参与度。

Medical genetics is a basic medical course that discusses the diagnosis, prevention and treatment of diseases in relation with genetic factors. This course requires students who have abilities of strong logical thinking, independent thinking, problem analyzing and solving. Single “cramming” teaching is difficult to mobilize students’ autonomous learning, and hardly achieves teaching effect of medical genetics. Teaching of case-based discussion breaks passive teaching mode in traditional class. The teacher throws out typically clinical cases. The students prepare materials around relevant problems of cases, and carry out class discussion. Then, key and difficult points of the course are integrated in teaching and learning interaction, which reaches a remarkable effect of teaching. Since 2013, the teaching and research group has carried out teaching of case-based discussion in undergraduates majoring in clinical medicine. In this paper, we screen and sort clinical cases on the basis of course teaching plan and case-based discussion in the teaching of medical genetics. The cases are summarized into 8 chapters in teaching case base, which basically cover the teaching of disease genetics and clinical genetics.The construction of teaching case base in medical genetics has realized the deep integration of clinical cases and teaching. Students can understand and master important and difficult points of teaching in a more intuitive way, which is helpful to stimulate students’ innovative thinking, improve students’ learning interest and class participation.