组蛋白变体H2A.Z的转录调控功能与动态作用机制
收稿日期: 2023-12-13
修回日期: 2024-02-27
网络出版日期: 2024-02-29
基金资助
国家自然科学基金项目(31870725);国家自然科学基金项目(32071204)
The roles and mechanisms of histone variant H2A.Z in transcriptional regulation
Received date: 2023-12-13
Revised date: 2024-02-27
Online published: 2024-02-29
Supported by
National Natural Science Foundation of China(31870725);National Natural Science Foundation of China(32071204)
孙朝冉, 吴旭东 . 组蛋白变体H2A.Z的转录调控功能与动态作用机制[J]. 遗传, 2024 , 46(4) : 279 -289 . DOI: 10.16288/j.yczz.23-307
H2A.Z, one of the most well-known variants of histone H2A, has been extensively investigated on its dual roles in gene transcription in recent years. In this review, we focus on the intricate involvement of H2A.Z in transcriptional regulation, including the assembly of distinct H2A.Z subtypes, post-translational modifications and genomic distributions. Emphasis is placed on the biological and pathophysiological implications, particularly in tumorigenesis and nervous system development. We summarize the dynamic regulatory mechanisms governing H2A.Z deposition or eviction on chromatin to provide insights for understanding the diversity of histone variants and promoting the search of new targets in concerned disease diagnosis and treatment.
Key words： epigenetic regulation; nucleosome; gene transcription; histone variant; H2A.Z
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