真核生物mRNA 3′非翻译区最新研究进展
收稿日期: 2024-09-27
修回日期: 2025-02-20
网络出版日期: 2025-02-25
基金资助
国家自然科学基金项目(U23A20230);黑龙江省自然科学基金(优秀青年项目);国家现代农业产业技术体系项目(CARS-41)
Recent advances in the study of 3′ untranslated regions of eukaryotic mRNAs
Received date: 2024-09-27
Revised date: 2025-02-20
Online published: 2025-02-25
Supported by
National Natural Science Foundation of China(U23A20230);Natural Science Fund for Outstanding Youth of Heilongjiang Province(YQ2023C008);China Agriculture Research System of MOF and MARA(CARS-41)
罗昊玉, 闫晓红, 牟芳, 王宁 . 真核生物mRNA 3′非翻译区最新研究进展[J]. 遗传, 2025 , 47(6) : 616 -624 . DOI: 10.16288/j.yczz.24-283
The 3′ untranslated regions (3′UTRs) are a component of eukaryotic messenger RNAs (mRNAs) and located at their 3′-most ends. 3′UTRs play crucial roles in post-transcriptional regulation of gene expression, regulating cleavage and polyadenylation, mRNA stability, mRNA translation and localization. With deepening research of the 3′UTRs, and with advent of various omics methods, a few unexpected functions of the eukaryotic 3′UTRs have been uncovered. In this review, we summarize recent advances in the study of 3′UTRs and propose the future research directions for studying the roles and mechanisms of the 3′UTRs, with the aim to provide a better reference for comprehensively investigating gene function and regulation.
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