N4-乙酰胞苷修饰在动物生殖发育中的研究进展
收稿日期: 2025-10-13
修回日期: 2025-12-17
网络出版日期: 2026-01-15
基金资助
国家重点研发计划子课题(2023YFD1300502-1);安徽省现代农业产业技术体系岗位专家项目(AHCYJSTX-04);安徽农业大学高层次人才科研启动项目(rc392504)
Progress on N4-acetylcytidine in animal reproductive development
Received date: 2025-10-13
Revised date: 2025-12-17
Online published: 2026-01-15
Supported by
Sub-project of the National Key Research and Development Program(2023YFD1300502-1);Expert Position Project of the Modern Agricultural Industry Technology System of Anhui Province(AHCYJSTX-04);Startup Foundation for High-level Talents of Anhui Agricultural University(rc392504)
祝新月, 胡坤隆, 徐雯睆, 轩梦庆, 甘信琪, 杨智元, 王文卓, 刘郑秋, 张梦雅, 周贝贝, 俞文杰, 张运海, 曹祖兵 . N4-乙酰胞苷修饰在动物生殖发育中的研究进展[J]. 遗传, 2026 , 48(3) : 272 -286 . DOI: 10.16288/j.yczz.25-267
N4-acetylcytidine (ac4C) is an emerging RNA epigenetic modification that has attracted considerable attention in the field of epitranscriptomics in recent years. This modification is widely present in tRNA, rRNA, mRNA, and various non-coding RNAs. By precisely regulating RNA stability and translational efficiency, ac4C modulates the expression network of downstream genes, thereby playing a critical role in cellular function. In this review, we summarize recent advances in the distribution patterns, biological functions, and regulatory mechanisms of ac4C, highlight the associated writer enzymes, detection methodologies, and the involvement of ac4C in animal reproductive development. We aim to provide a solid theoretical foundation and valuable research insights for future investigations into the regulatory mechanisms of ac4C modification in animal and human reproduction.
Key words： ac4C; RNA modification; epigenetics; gamete maturation; embryonic development
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