MicroRNA调控动物脂肪细胞分化研究进展

doi:10.16288/j.yczz.15-233

遗传 ›› 2015, Vol. 37 ›› Issue (12): 1175-1184.doi: 10.16288/j.yczz.15-233

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MicroRNA调控动物脂肪细胞分化研究进展

张进威, 罗毅, 王宇豪, 何刘军, 李明洲, 王讯

四川农业大学动物科技学院,动物遗传育种研究所,成都 611130

收稿日期:2015-05-20 出版日期:2015-12-20 发布日期:2015-09-16
通讯作者: 王讯,副教授,硕士生导师,研究方向：猪遗传育种与繁殖。E-mail:wangxun99@163.com E-mail:JinweiZhang50@163.com
作者简介:张进威,硕士研究生,专业方向：猪遗传育种与繁殖。E-mail: JinweiZhang50@163.com
基金资助:
国家高技术研究发展计划(863计划)项目(编号：2013AA102502),四川省教育厅重点项目(编号：15ZA0008/15ZA0003),四川省青年科技创新研究团队(编号：2015TD0012),长江学者和创新团队发展计划(编号：IRT13083)和重庆市农发资金项目(编号：13410)资助

MicroRNA regulates animal adipocyte differentiation

Jinwei Zhang, Yi Luo, Yuhao Wang, Liujun He, Mingzhou Li, Xun Wang

College of Animal Science and Technology, Institute of Animal Genetics and Breeding, Sichuan Agricultural University,Chengdu 611130, China

Received:2015-05-20 Online:2015-12-20 Published:2015-09-16

摘要/Abstract

摘要： 脂肪组织不仅在维持机体能量代谢和稳态上发挥重要作用,同时也是重要的内分泌器官。脂肪细胞分化是由间充质干细胞(Mesenchymal stem cells, MSC)向成熟脂肪细胞分化的复杂生理过程,该过程由大量转录因子、激素、信号通路分子协同调控。miRNA作为内源性非编码RNA,主要通过抑制转录后翻译等机制来调控基因表达。近年来越来越多的证据表明miRNA通过调控脂肪细胞分化相关的转录因子和重要信号分子进而影响动物脂肪细胞的分化和脂肪形成。本文对miRNA影响动物白色、棕色和米色脂肪细胞分化的作用机制及其相关调控通路和关键因子进行了归纳总结,以期为肥胖等代谢性疾病的治疗提供一定的理论指导和新的治疗思路。

关键词: miRNA, 白色脂肪细胞, 棕色脂肪细胞, 米色脂肪细胞, 分化

Abstract: Adipose tissues play a critical role in the regulation of energy metabolism and homeostasis, and is also an important endocrine organ. Adipocyte differentiation is a complicated physiological process during which mesenchymal stem cells differentiate into adipocytes. This process is synergistically regulated by a large number of transcription factors, hormones and signaling pathway molecules. As a class of endogenous non-coding RNA (ncRNA), microRNAs (miRNAs) regulate gene expression mainly through post-transcriptional translational repression. In recent years, numerous studies have demonstrated that miRNA could have an impact on adipocyte differentiation and adipogenesis by modulating the expression levels of several adipogenic transcription factors and key signaling molecules. In this review, we summarize the mechanism of miRNA in regulating the differentiation of white/brown/beige adipocytes and the relevant signaling pathways and key factors, in the hope of providing theoretical guidance and new thoughts for treating obesity and other metabolic diseases.

Key words: miRNA, white adipocyte, brown adipocyte, beige adipocyte, differentiation

张进威, 罗毅, 王宇豪, 何刘军, 李明洲, 王讯. MicroRNA调控动物脂肪细胞分化研究进展[J]. 遗传, 2015, 37(12): 1175-1184.

Jinwei Zhang, Yi Luo, Yuhao Wang, Liujun He, Mingzhou Li, Xun Wang. MicroRNA regulates animal adipocyte differentiation[J]. HEREDITAS(Beijing), 2015, 37(12): 1175-1184.

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MicroRNA调控动物脂肪细胞分化研究进展

MicroRNA regulates animal adipocyte differentiation

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