脂肪组织DNA甲基化与糖尿病和肥胖的发生发展

doi:10.16288/j.yczz.18-206

遗传 ›› 2019, Vol. 41 ›› Issue (2): 98-110.doi: 10.16288/j.yczz.18-206

脂肪组织DNA甲基化与糖尿病和肥胖的发生发展

黄鑫,陈永强,徐国良,彭淑红()

江西中医药大学,中医基础理论分化发展研究中心,南昌330004

收稿日期:2018-09-10 修回日期:2018-11-03 出版日期:2019-02-20 发布日期:2018-12-06
作者简介:黄鑫,硕士研究生,专业方向：中医药防治代谢性疾病。E-mail: 1103763638@qq.com
基金资助:
国家自然科学基金项目(81503315);国家自然科学基金项目(81560744);国家留学基金委项目(201608360175)

DNA methylation in adipose tissue and the development of diabetes and obesity

Huang Xin,Chen Yongqiang,Xu Guoliang,Peng Shuhong()

Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine (TCM), Jiangxi University of TCM, Nanchang 330004, China

Received:2018-09-10 Revised:2018-11-03 Online:2019-02-20 Published:2018-12-06
Supported by:
[Supported by the National Natural Science Foundation of China(81503315);[Supported by the National Natural Science Foundation of China(81560744);China Scholarship Council](201608360175)

摘要/Abstract

摘要：

糖尿病和肥胖是经常一起出现的复杂性代谢疾病,均受遗传因素和环境因素双重影响。越来越多的研究表明,DNA甲基化的变化会导致糖尿病和肥胖的发生。脂肪组织是糖尿病和肥胖主要的受累组织,同时作为内分泌器官参与多种病理生理过程,调节机体代谢平衡。脂肪组织相关基因的DNA甲基化变化会影响脂肪组织功能,从而与糖尿病和肥胖的发生密切相关。本文主要阐述糖尿病患者和肥胖患者不同类型脂肪组织DNA甲基化变化,以期深入了解糖尿病和肥胖发生发展的可能机制和探寻可能的防治途径。

关键词: 糖尿病, 脂肪组织, DNA甲基化

Abstract:

Diabetes and obesity are complicated metabolic diseases which frequently occur together and are affected by environmental, hereditary and metabolic factors. Adipose tissue is involved in various physiological and pathological processes and plays an essential role as an endocrine organ which regulates the metabolic balance of the body. DNA methylation of some genes in adipose tissue may have an impact on its function. A growing body of evidence suggests that changes in DNA methylation may alter gene expression and lead to the development of diabetes and obesity in which adipose tissue function is imbalanced. This review discusses recent advances in alterations of DNA methylation in different types of adipose tissue in individuals with diabetes and obesity. This evidence may lead to a greater understanding of the pathogenesis of these diseases and lead to potential therapeutic interventions and management strategies for diabetes and obesity.

Key words: diabetes, adipose tissue, DNA methylation

黄鑫,陈永强,徐国良,彭淑红. 脂肪组织DNA甲基化与糖尿病和肥胖的发生发展[J]. 遗传, 2019, 41(2): 98-110.

Huang Xin,Chen Yongqiang,Xu Guoliang,Peng Shuhong. DNA methylation in adipose tissue and the development of diabetes and obesity[J]. Hereditas(Beijing), 2019, 41(2): 98-110.

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脂肪组织DNA甲基化与糖尿病和肥胖的发生发展

DNA methylation in adipose tissue and the development of diabetes and obesity

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