遗传 ›› 2020, Vol. 42 ›› Issue (2): 145-152.doi: 10.16288/j.yczz.19-253
杨岸奇1,2,3(), 陈斌1,3(), 冉茂良1,3(), 杨广民2, 曾诚2
收稿日期:
2019-08-28
修回日期:
2020-02-08
出版日期:
2020-02-17
发布日期:
2020-02-19
基金资助:
Anqi Yang1,2,3(), Bin Chen1,3(), Maoliang Ran1,3(), Guangmin Yang2, Cheng Zeng2
Received:
2019-08-28
Revised:
2020-02-08
Online:
2020-02-17
Published:
2020-02-19
Supported by:
摘要:
基因组选择是指在全基因组范围内通过基因组中大量的标记信息估计出个体全基因组范围的育种值,可进一步提升育种效率和准确性,目前在猪纯繁育种中得到广泛应用。但有研究表明,现有的基因组选择方法在猪杂交育种上的应用效果并不理想,在跨群体条件下预测准确性极低。杂交作为养猪业中最为广泛的育种手段之一,通过结合基因组选择理论进一步提升猪的生产性能,具有重要的经济和研究价值。本文综述了基因组选择的发展及其在猪育种中的应用现状,并结合国内外猪杂交育种的方式,分析了目前基因组选择方法在猪杂交育种应用方面的不足,旨在为未来基因组选择在猪杂交育种中的合理应用提供参考。
杨岸奇, 陈斌, 冉茂良, 杨广民, 曾诚. 基因组选择在猪杂交育种中的应用[J]. 遗传, 2020, 42(2): 145-152.
Anqi Yang, Bin Chen, Maoliang Ran, Guangmin Yang, Cheng Zeng. The application of genomic selection in pig cross breeding[J]. Hereditas(Beijing), 2020, 42(2): 145-152.
表1
基因组选择在猪繁殖性状方面的研究"
主要研究性状 | 主要结论 | 文献来源 |
---|---|---|
总产仔数(h2=0.16); 流产率(h2=0.16) | 两种性状GEBV和EBV估计值的平均准确性分别为0.82、0.83;当不断有高胎次母猪作为研究对象时基因组选择准确性分别降低至0.33~0.65范围内。 | |
窝总产仔数 | 利用一步法计算的母猪基因组育种值准确性为0.28~0.49,传统BLUP的育种值准确性为0.22;公猪无显著差异。 | |
窝总产仔数 | GEBV值计算准确性比养殖公司宣称的计算结果准确性高20%。 | |
总产仔数(不同群体h2分别 为0.21,0.14,0.19) | 表型值的实际值与预测值的平均相关性总是高于传统方法,杂交群体高0.26,纯繁群体高0.15~0.22。 | |
繁殖阶段总产仔数, 窝总产仔数,死亡率 | 对比一步法、GBLUP、传统BLUP法等预测结果发现:一步法、GBLUP法预测准确性平均为0.171和0.209,BLUP法准确性平均为0.091。 | |
总产仔数 | 与传统方法比,一步法使结果准确性提升19%且认为基因组选择的准确性高于传统的系谱指数和育种值选种,且低遗传力性状提高幅度最大。 |
表2
基因组选择在生长性状与肉质性状方面的研究结果"
主要研究性状 | 主要结论 | 文献来源 |
---|---|---|
生长速度、背膘厚度、肉品质、饲料利用率、肌内脂肪含量 | GBLUP提升遗传进展,减少近交系数。基因组选择比传统选择方法对性状的遗传进展提升高27%~33%。候选群体中只有亲缘关系和表型值明确的条件下,基因组选择对遗传改良速度的增加效果不明显。 | |
平均日增重、背膘厚 | 利用基因组选择和RRBLUP法对性状的遗传进展有很大促进作用。利用高密度芯片可以降低连锁不平衡对性状的影响。 | |
采食量、平均日增重、背膘厚、肌肉厚度、肌内脂肪含量 | 使用Bayes-A法,无论高密度芯片和低密度芯片对基因进行分析都不能使GEBV值获得较高准确性。 | |
日采食量、平均日增重、 背膘厚 | 日采食量、平均日增重、背膘厚GEBV准确性分别为0.508~0.531、0.506~0.532、0.308~0.362。 | |
宰后45 min猪体温度和 眼肌pH值 | 相比于RRBLUP、Bayes-A和Bayes-B等模型,异方差统计模型可增强GEBV的准确性,但准确性提高幅度较小。 |
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