遗传 ›› 2008, Vol. 30 ›› Issue (4): 413-418.doi: 10.3724/SP.J.1005.2008.00413

• 综述 • 上一篇    下一篇

酒精依赖相关基因的遗传多态性

贺艮峰, 钟树荣, 景强   

  1. 昆明医学院法医学院, 昆明 650031

  • 收稿日期:2007-10-04 修回日期:2008-01-17 出版日期:2008-04-10 发布日期:2008-04-10
  • 通讯作者: 景强

Genetic polymorphism for genes of alcohol dependence

HE Gen-Feng, ZHONG Shu-Rong, JING Qiang   

  1. Department of Forensic Medicine, Kunming Medical College, Kunming 650031, China

  • Received:2007-10-04 Revised:2008-01-17 Online:2008-04-10 Published:2008-04-10
  • Contact: JING Qiang

摘要:

酒精依赖综合征受到复杂的生理、心理、个体遗传及环境等诸多因素的影响。有关研究已经证实了某些候选基因和酒精依赖密切相关。文章主要对与酒精依赖相关的酒精代谢关键酶(乙醇脱氢酶和乙醛脱氢酶以及细胞色素P450 2E1)基因以及调节神经递质作用的酶和受体(儿茶酚氧位甲基转移酶, 多巴胺受体D2、D4, μ阿片受体)基因遗传多态性研究作一综述。

关键词: 多态性, 基因, 遗传, 酒精依赖

Abstract:

Alcohol dependence is a complex disorder which is influenced by physiological, psychological, environmental factors, individual inheritance and so on. Several candidate genes associated with alcohol dependence risk have been identified. The review focuses on several related genes that control alcohol metabolism such as alcohol dehydrogenase, aldehyde dehydrogenase, cytochrome P450 2E1 and regulate neurotransmission such as catechol-O-methyltransferase, dopamine receptors D2 and D4, and mu opioid receptor.