遗传 ›› 2009, Vol. 31 ›› Issue (7): 683-689.doi: 10.3724/SP.J.1005.2009.00683

• 综述 • 上一篇    下一篇

siRNA的体内递送

师明磊;赵志虎;王洋;陈惠鹏   

  1. 军事医学科学院生物工程研究所, 北京 100071
  • 收稿日期:2008-10-30 修回日期:2009-12-19 出版日期:2009-07-10 发布日期:2009-07-10
  • 通讯作者: 赵志虎

In vivo delivery of siRNA

SHI Ming-Lei;ZHAO Zhi-Hu;WANG Yang;CHEN Hui-Peng   

  1. Beijing Institute of Biotechnology, Beijing 100071, China
  • Received:2008-10-30 Revised:2009-12-19 Online:2009-07-10 Published:2009-07-10
  • Contact: ZHAO Zhi-Hu

摘要: siRNA是一种由siRNA介导的转录后基因沉默。自利用RNAi沉默目的基因获得成功以来, 体内应用RNAi的研究受到高度重视。由于siRNA本身的不稳定性以及体内的复杂环境, siRNA递送的安全性与有效性成为目前关注的重点。文章就目前报道的siRNA体内递送方式进行了综述。

关键词: siRNA递送, siRNA, RNAi

Abstract: RNA interference (RNAi) is a mechanism of posttranscriptional gene silencing mediated by small interfering RNA (siRNA). The ability of synthetic siRNA to silence genes in vivo has made it well suited as therapeutic drug, but the instability and polarity of siRNA and the complexity of in vivo circumstances retarded rapid development of RNAi-based therapies. In this review, a summary of the advances on in vivo siRNA delivery is presented and discussed.