母源效应蛋白在基因组印记维持中的作用

doi:10.3724/SP.J.1005.2014.0959

遗传 ›› 2014, Vol. 36 ›› Issue (10): 959-964.doi: 10.3724/SP.J.1005.2014.0959

• 综述 • 下一篇

母源效应蛋白在基因组印记维持中的作用

马馨^1,2,张胜²,杨树宝¹,王晓晨¹,朱屹然¹,李子义²,栾维民¹

1. 吉林农业大学动物科技学院,动物生产及产品质量安全教育部重点实验室,长春 130118;
2. 吉林大学动物医学学院,长春 130062

收稿日期:2014-06-20 出版日期:2014-10-20 发布日期:2014-10-20
通讯作者: 栾维民,博士,教授,研究方向：免疫器官发生发育。E-mail: luanweimin@aliyun.com;李子义,博士,教授,研究方向：动物克隆与转基因动物。E-mail: ziyi@jlu.edu.cn E-mail:maxin3202@163.com
作者简介:马馨,博士,副教授,研究方向：动物克隆与转基因动物。E-mail: maxin3202@163.com
基金资助:
国家自然科学基金青年基金项目(编号：31302047)资助

The roles of maternal-effect proteins in the maintenance of genomic imprints

Xin Ma^{1, 2}, Sheng Zhang², Shubao Yang¹, Xiaochen Wang¹, Yiran Zhu¹, Ziyi Li², Weimin Luan¹

1. College of Animal Science and Technology, Key Laboratory of Animal Production and Production Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun 130118, China;
2. College of Veterinary Medicine, Jilin University, Changchun 130062, China

Received:2014-06-20 Online:2014-10-20 Published:2014-10-20

摘要/Abstract

摘要： 基因组印记是指生殖细胞发生过程中双亲基因组发生差异表观修饰,使带有亲代印记的等位基因出现父源或母源单等位基因表达。在配子发生和早期胚胎发育过程中,基因组印记甲基化经历一个去除、重建和维持的复杂过程。这个过程中的任何环节被干扰都将导致印记紊乱,造成胚胎发生、胎盘形成及出生后发育异常。近来研究表明,早期胚胎发育过程中一些母源效应蛋白在印记基因表观调控中起重要作用。为了更好地理解这些母源因子对印记基因建立及维持的作用与机制,文章综述了DPPA3、ZFP57、TRIM28和DNMT1等母源效应因子近年来的相关研究进展,并探讨了这些因子对基因组印记的表观调控机制。

关键词: 基因组印记, 母源调控基因, DNA甲基化, 植入前胚胎

Abstract: Genomic imprinting is a mechanism of differentially epigenetic modification that restricts monoallelic expression to either the maternally or paternally inherited copy of the gene during gametogenesis. Imprinted methylation undergoes a process of erasure, acquisition, and maintenance during gametogenesis and early embryogenesis. Disruptions in any of these steps may lead to imprinting disorders, resulting in the aberrant development of embryogenesis, placentation and postnatal growth. Recent studies have shown that maternal-effect proteins are important for the regulation of imprinted gene during the development of preimplantation embryos. In order to obtain a better understanding for the mechanism of maternal-effect proteins in the maintenance of genomic imprints, the recent study progress of maternal-effect proteins, such as DPPA3, ZFP57, TRIM28 and DNMT1, are summarized, and the regulation mechanism of these maternal-effect proteins for genomic imprints are discussed.

Key words: genomic imprinting, maternal-effect genes, DNA methylation, preimplantation embryos

马馨,张胜,杨树宝,王晓晨,朱屹然,李子义,栾维民. 母源效应蛋白在基因组印记维持中的作用[J]. 遗传, 2014, 36(10): 959-964.

Xin Ma, Sheng Zhang, Shubao Yang, Xiaochen Wang, Yiran Zhu, Ziyi Li, Weimin Luan. The roles of maternal-effect proteins in the maintenance of genomic imprints[J]. HEREDITAS(Beijing), 2014, 36(10): 959-964.

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母源效应蛋白在基因组印记维持中的作用

The roles of maternal-effect proteins in the maintenance of genomic imprints

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