泛素化修饰调控脱落酸介导的信号途径

doi:10.16288/j.yczz.17-043

遗传 ›› 2017, Vol. 39 ›› Issue (8): 692-706.doi: 10.16288/j.yczz.17-043

泛素化修饰调控脱落酸介导的信号途径

于菲菲¹(),谢旗^1,²()

1. 中国科学院遗传与发育生物学研究所,国家植物基因研究中心,植物基因组学国家重点实验室,北京 100101
2. 中国科学院大学生命科学学院,北京 100049

收稿日期:2017-02-13 修回日期:2017-03-24 出版日期:2017-08-20 发布日期:2017-12-25
作者简介:于菲菲,博士,工程师,研究方向：泛素介导的蛋白修饰及植物逆境胁迫信号传导的分子机制。E-mail: ffyu@genetics.ac.cn|谢旗，博士，研究员，博士生导师，研究方向：泛素介导的蛋白修饰及植物逆境胁迫信号传导的分子机制。E-mail: qxie@genetics.ac.cn|谢旗课题组主要研究方向是植物激素信号调控和泛素蛋白调控的分子机制的研究。在建立植物蛋白泛素化研究系列方法学的基础上，以拟南芥、水稻和小盐芥为研究材料，系统鉴定分析了高等植物蛋白泛素化调控的关键因子。重点解析泛素蛋白介导的植物生长素和脱落酸及植物ERAD复合物在逆境信号转导中的重要调控机制。揭示了耐盐植物小盐芥的耐盐机制和蛋白泛素化介导的植物病毒与寄主互作的重要调控作用。相关研究成果发表在Nature、Trends in Plant Science、Cell Research、PNAS、Plant Cell、Molecular Plant等期刊上。相关研究论文多次被Nature Review of Microbiology和Faculty of 1000等专文评述，在相关领域产生了重要的国际影响。发表的文章被他引超过6750次，2016年被国际知名汤姆逊?路透社(Thomson Reuters)评为全球引文桂冠奖科学家。
基金资助:
国家重点基础研究发展规划(973计划)项目(2011CB915402)

Ubiquitination modification precisely modulates the ABA signaling pathway in plants

Feifei Yu¹(),Qi Xie^1,²()

1. State Key Laboratory of Plant Genomics, National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
2. College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China

Received:2017-02-13 Revised:2017-03-24 Online:2017-08-20 Published:2017-12-25
Supported by:
the National Basic Research Program of China (973 Program)(2011CB915402)

摘要/Abstract

摘要：

泛素化修饰是一种重要的蛋白质翻译后修饰,通过调节蛋白的活性和稳定性等影响其功能的发挥,在真核生物的生命过程中具有非常重要的作用。泛素化修饰通过精细地调控植物激素脱落酸(abscisic acid, ABA)的合成和信号转导过程的关键因子,影响植物对ABA的响应,参与植物生长发育过程及对干旱、盐和冷胁迫等不良环境的应答。本文概述了植物中泛素化修饰的相关组分(包括泛素连接酶E3、泛素结合酶E2、26S蛋白酶体)和内膜运输相关蛋白,以及这些蛋白调控ABA合成和信号转导过程的最新研究进展,提出该研究领域需要解决的新问题,以期为相关领域的科研人员进一步了解翻译后修饰如何调控激素信号的转导途径提供参考。

关键词: 脱落酸, 泛素连接酶E3s, 内膜运输, 泛素

Abstract:

Protein post-translational modification by ubiquitination is essential for the activity and stability of proteins in the eukaryotic life cycle. In the past few years, it has been found that ubiquitination subtly modulates the abscisic acid (ABA) signaling pathway to regulate plant growth, development and stress responses, such as drought, salinity and cold stress responses. In this review, how the ubiquitin-proteasome system and ubiquitination-related membrane trafficking pathway affect ABA synthesis and signal transduction will be addressed and analysed. Also, the challenging questions in this field will be raised. These comprehensive views on the regulatory role of ubiquitination modification in the ABA pathway will shed light on future researches on how the ubiquitination-related process affects other hormone signaling pathways.

Key words: abscisic acid (ABA), E3 ubiquitin ligase, membrane trafficking, ubiquitin

于菲菲,谢旗. 泛素化修饰调控脱落酸介导的信号途径[J]. 遗传, 2017, 39(8): 692-706.

Feifei Yu,Qi Xie. Ubiquitination modification precisely modulates the ABA signaling pathway in plants[J]. Hereditas(Beijing), 2017, 39(8): 692-706.

参考文献

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泛素化修饰调控脱落酸介导的信号途径

Ubiquitination modification precisely modulates the ABA signaling pathway in plants

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