逆转录转座子LINE-1与肿瘤的发生和发展

doi:10.16288/j.yczz.15-470

遗传 ›› 2016, Vol. 38 ›› Issue (2): 93-102.doi: 10.16288/j.yczz.15-470

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逆转录转座子LINE-1与肿瘤的发生和发展

刘茜¹,王瑾晖²,李晓宇¹,岑山¹

1. 中国医学科学院&北京协和医学院医药生物技术研究所免疫生物学室,北京 100050;
2. 中国医学科学院&北京协和医学院北京协和医院妇产科,北京 100730

收稿日期:2015-11-16 修回日期:2015-12-02 出版日期:2016-02-20 发布日期:2016-01-05
通讯作者: 李晓宇,博士,副研究员,研究方向：病毒学。E-mail: xiaoyulik@hotmail.com
岑山,博士,研究员,研究方向：病毒学。E-mail: shancen@hotmail.com
作者简介:刘茜,硕士研究生,专业方向：MOV10抑制LINE-1分子机制的研究。E-mail: shine_lqian@163.com
基金资助:
国家自然科学基金项目(编号：31270210)资助[Supported by the National Natural Science Foundation of China (No.31270210)]

The connection between LINE-1 retrotransposition and human tumorigenesis

Qian Liu¹, Jinhui Wang², Xiaoyu Li¹, Shan Cen¹

1. Department of Immunology, Institute of Medicinal Biotechnology, Chinese academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;
2. Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Received:2015-11-16 Revised:2015-12-02 Online:2016-02-20 Published:2016-01-05

摘要/Abstract

摘要： LINE-1是现今人体内存在的唯一具有自主转座活性的转座子,约有500 000个拷贝,占人类基因组总量的17%。LINE-1是通过转录和逆转录在内的转座过程产生新的DNA拷贝,并使新产生的DNA拷贝插入基因组的不同位置。LINE-1转座会影响基因组中其他基因的表达或调控,因而会对基因组的稳定性产生影响,从而导致基因疾病或肿瘤的发生。本文总结了近年来国际上对LINE-1转座与肿瘤的发生和发展之间关系的研究进展,为肿瘤的治疗和机制研究提供一些线索。

关键词: 转座, 逆转录转座子, 基因组, LINE-1, 肿瘤, 基因稳定性, 逆转录酶

Abstract: LINE-1 is the only currently known active autonomous transposon in humans with an estimated 500 000 copies representing 17% of the human genome. LINE-1 propagates itself through a process called retrotransposition, which includes transcription and reverstranscription, to produce new DNA copies. The new produced DNA copies can integrate into new genomic loci. The insertion of LINE-1 is able to cause genetic instability by affecting the expression or regulation of the nearby genes, thus causing dozens of genetic diseases or tumors. In this review, we summarize the recent research progress on the connection between LINE-1 retrotransposition and human tumorigenesis, which might shed light on the biology mechanisms and treatment of the tumorigenesis.

Key words: transposition, retrotransposon, genome, LINE-1, tumor, genetic instability, reverstranscriptease

刘茜,王瑾晖,李晓宇,岑山. 逆转录转座子LINE-1与肿瘤的发生和发展[J]. 遗传, 2016, 38(2): 93-102.

Qian Liu, Jinhui Wang, Xiaoyu Li, Shan Cen. The connection between LINE-1 retrotransposition and human tumorigenesis[J]. HEREDITAS(Beijing), 2016, 38(2): 93-102.

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逆转录转座子LINE-1与肿瘤的发生和发展

The connection between LINE-1 retrotransposition and human tumorigenesis

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