遗传 ›› 2018, Vol. 40 ›› Issue (8): 607-619.doi: 10.16288/j.yczz.17-393

• 综述 •    下一篇

真核生物mRNA翻译起始机制研究进展

郑超星1,马小凤1,张永华1,李洪杰2,张根发1()   

  1. 1. 北京师范大学生命科学学院,北京 100875
    2. 中国农业科学院作物科学研究所,北京 100081
  • 收稿日期:2018-04-09 修回日期:2018-06-25 出版日期:2018-08-16 发布日期:2018-07-12
  • 通讯作者: 张根发 E-mail:gfzh@bnu.edu.cn
  • 作者简介:郑超星,硕士研究生,专业方向:植物分子遗传学。E-mail: superstarz@163.com
  • 基金资助:
    国家自然科学基金项目资助(31470399)

Research progress in the mechanism of translation initiation of eukaryotic mRNAs

Zheng Chaoxing1,Ma Xiaofeng1,Zhang Yonghua1,Li Hongjie2,Zhang Genfa1()   

  1. 1. College of Life Sciences, Beijing Normal University, Beijing 100875, China
    2. Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China
  • Received:2018-04-09 Revised:2018-06-25 Online:2018-08-16 Published:2018-07-12
  • Contact: Zhang Genfa E-mail:gfzh@bnu.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China(31470399)

摘要:

在真核生物中,mRNA翻译是一个复杂的多步骤过程,包括起始、延伸和终止3个阶段。其中,起始阶段的调控是影响mRNA翻译的关键。目前已经发现,mRNA翻译起始方式有多种,以最早发现的m 7G帽依赖性扫描机制最为经典,但当细胞处于逆境,经典起始机制受到抑制时,其他类型的起始机制会将其替代以保证翻译的顺利进行。本文对目前已发现的真核生物mRNA不同翻译起始机制特别是经典起始机制的替代机制进行了综述,旨在为深入认识真核生物基因在翻译水平上的表达调控提供参考。

关键词: 翻译起始, 真核生物mRNA, 帽依赖性扫描, IRES, CITE

Abstract:

The translation of mRNA is a complicated multi-step process, including initiation, elongation and termination. Among them, the regulation of the initial stage plays the key role. There are many ways to initiate mRNA translation, and the most classical way is the m 7G cap-dependent scanning mechanism that was also the first mechanism identified. When cells encounter adversity and the classical mechanism is inhibited, other types of translation initiation mechanisms will be activated. In this review, we summarize the translation initiation mechanisms of eukaryotic mRNAs, especially some alternative mechanisms. It will provide a reference for further understanding of the expression and regulation of eukaryotic genes at the translation levels.

Key words: translate initiation, eukaryotic mRNA, m 7G cap-dependent scanning, IRES, CITE