遗传 ›› 2019, Vol. 41 ›› Issue (8): 677-685.doi: 10.16288/j.yczz.19-126

• 综述 • 上一篇    下一篇

精神分裂症相关单核苷酸多态性调控microRNA功能研究进展

梁文权1,侯豫2,赵存友1()   

  1. 1. 南方医科大学基础医学院医学遗传学教研室,广州 510515
    2. 陆军总医院附属八一儿童医院神经发育科,北京 100700
  • 收稿日期:2019-05-08 修回日期:2019-07-07 出版日期:2019-08-20 发布日期:2019-08-05
  • 通讯作者: 赵存友 E-mail:cyzhao@smu.edu.cn
  • 作者简介:梁文权,硕士在读研究生,专业方向:表观遗传。E-mail:wen1390229749@163.com
  • 基金资助:
    广东省科技计划项目(2019B030316032);广州市科技计划项目(201804010259);国家自然科学基金项目资助(81601175);国家自然科学基金项目资助(81671333)

Schizophrenia-associated single nucleotide polymorphisms affecting microRNA function

Liang Wenquan1,Hou Yu2,Zhao Cunyou1()   

  1. 1. Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
    2. Department of Pediatric Neurology, Affiliated BaYi Children's Hospital, PLA Army General Hospital, Beijing 100700, China
  • Received:2019-05-08 Revised:2019-07-07 Online:2019-08-20 Published:2019-08-05
  • Contact: Zhao Cunyou E-mail:cyzhao@smu.edu.cn
  • Supported by:
    Supported by the Guangdong Science and Technology Foundation(2019B030316032);The Guangzhou Science and Technology Foundatio(201804010259);The National Natural Science Foundation of China(81601175);The National Natural Science Foundation of China(81671333)

摘要:

MicroRNA (miRNAs)是一类长约22nt且对基因表达具有广泛的调控作用的非编码RNA,并在神经元增殖、分化和发育成熟的过程中扮演重要角色。近年来全基因组关联研究(genome-wide association studies, GWAS)发现了众多的精神分裂症相关单核苷酸多态性(single nucleotide polymorphisms, SNPs)位点多位于非编码区,表明miRNA在精神分裂症的发病过程中存在重要作用。本文综述了精神分裂症相关SNP与miRNA可能发生相互作用的4种机制(SNP位于miRNA基因、SNP位于miRNA宿主基因、SNP位于miRNA种子序列和SNP位于miRNA结合位点),为研究miRNA在精神分裂症发生发展中的作用提供参考。

关键词: 全基因组关联研究, 单核苷酸多态性, 微小RNA, 精神分裂症

Abstract:

MicroRNAs (miRNAs) compose a class of non-coding transcripts with a mean length of 22 nucleotides, and play critical roles in regulating gene expression in the process of development, proliferation and differentiation of neurons. Recent genome-wide association studies (GWAS) find most of schizophrenia-associated single nucleotide polymorphisms (SNPs) locating in the non-coding regions, providing functional implications of miRNAs in the development of schizophrenia. In this review, we highlight the interplays between GWAS-SNPs and miRNAs in four perspectives: SNP in miRNA gene; miRNA located in the host gene; SNP located in the miRNA’s seed sequence; SNP located in the miRNA’s binding site. We also speculate on the future research on the role of miRNA in the development of schizophrenia.

Key words: GWAS, SNP, miRNA, schizophrenia