长链非编码RNA通过细胞核高级结构调控真核基因表达及其临床意义

doi:10.16288/j.yczz.16-385

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (3): 189-199.doi: 10.16288/j.yczz.16-385

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The mechanism and clinical significance of long noncoding RNA-mediated gene expression via nuclear architecture

Jian Shi^1,²(),Yanming Li^1,²,Xiangdong Fang^1,²()

1. CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
2. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2016-11-18 Revised:2017-01-19 Online:2017-03-20 Published:2017-02-23
Supported by:
the National Natural Science Foundation of China(31471115, 31401160, 81670109)

Abstract

Abstract:

Long noncoding RNAs (lncRNAs) are a class of non-protein coding transcripts exceeding 200 nucleotides in length. Accumulating evidence achieved by several sophisticated techniques such as chromatin conformation capture and RNA-seq has led to new questions concerning correlations between lncRNAs and chromatin structures. Many studies have revealed that lncRNAs exert great influences on gene expression through regulating chromatin 3D structures. In addition, lncRNAs play a crucial role in tumorigenesis and therefore hold great promises in disease diagnosis and prognosis. Here, we mainly focus on introducing how lncRNAs regulate gene expression by modulating nuclear architecture and discussing clinical values of lncRNAs in oncotherapy.

Key words: lncRNA, nuclear architecture, gene expression regulation, molecular biomarker

Jian Shi,Yanming Li,Xiangdong Fang. The mechanism and clinical significance of long noncoding RNA-mediated gene expression via nuclear architecture[J]. Hereditas(Beijing), 2017, 39(3): 189-199.

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