乳腺癌中雌激素受体α表达水平调节的分子机制

doi:10.3724/SP.J.1005.2010.00191

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (3): 191-197.doi: 10.3724/SP.J.1005.2010.00191

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Molecular mechanisms of regulation of estrogen receptor a expression level in breast cancer

CHENG Long,HUANG Cui-Fen,YE Qi-Nong

Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100850, China

Received:2009-11-24 Revised:2010-02-04 Online:2010-03-20 Published:2010-03-15
Contact: YE Qi-Nong E-mail:yeqn66@yahoo.com

Abstract

Abstract:

Estrogen receptor α(ERα) plays an important role in breast cancer development and progression and thus becomes a useful molecular target for breast cancer therapy. ERα is differentially expressed in breast cancer patients. Moreover, ERα expression levels may change at different stages of breast cancer even for the same patient. ERα expression is closely associated with the effect of endocrine therapy and prognosis. The mechanisms underlying ERα expression are complicated, because ERα expression is regulated at different levels, including chromatin, transcriptional, post- transcriptional, translational, and post-translational levels. Many proteins modulate the transcription of ERα gene at the chromatin and transcriptional levels through direct or indirect interaction with the ERα promoter. Some microRNAs decrease ERα levels possibly by induction of the degradation of ERα mRNA and/or repression of the mRNA translation. At the post-translational level, many proteins regulate ERα protein levels through ubiquitin-proteosome pathway. This review focuses on molecular mechanisms of regulation of ERa expression at different levels.

Key words: breast cancer, gene expression regulation, estrogen receptor α

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Molecular mechanisms of regulation of estrogen receptor a expression level in breast cancer

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