选择性多聚腺苷酸化的生物学效应及其调控机制研究进展

doi:10.16288/j.yczz.20-200

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Hereditas(Beijing) ›› 2021, Vol. 43 ›› Issue (1): 4-15.doi: 10.16288/j.yczz.20-200

• Review • Previous Articles Next Articles

Advances of functional consequences and regulation mechanisms of alternative cleavage and polyadenylation

Haidong Xu^1,^2,³, Bolin Ning^1,^2,³, Fang Mu^1,^2,³, Hui Li^1,^2,³, Ning Wang^1,^2,³()

^1. Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China
^2. Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China
^3. College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China

Received:2020-07-07 Revised:2020-10-19 Online:2021-01-20 Published:2020-12-11
Contact: Wang Ning E-mail:wangning@neau.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China Nos(31572392);Supported by the National Natural Science Foundation of China Nos(3187131154);the China Agriculture Research System No(CARS-41)

Abstract

Abstract:

During the maturation of pre-mRNAs and some lncRNAs, their 3'ends are cleaved and polyadenylated. The cleavage and polyadenylation (C/P) require the presence of a polyadenylation signal (PAS) at the RNA 3?end. Most eukaryotic genes have multiple PASs, resulting in alternative cleavage and polyadenylation (APA). APA leads to transcript isoforms with different coding potentials and/or variable 3?UTRs. The 3'UTR affects mRNA stability, translation, transportation, and cellular localization. Therefore, APA is an important mechanism of posttranscriptional gene regulation in eukaryotes. In recent years, whole genome sequencing of animals, plants and yeast has revealed that APA is pervasive in eukaryotes, and the functional consequences and regulation of APA have been studied. To date, many cis-acting regulatory elements and trans-acting factors for APA regulation have been identified. In this review, we summarize the recent advances in the functional consequences and regulation of APA and discuss the future directions, aiming to provide clues and references for future APA study.

Key words: gene expression regulation, alternative cleavage and polyadenylation, polyadenylation signal, cis- acting regulatory element, trans-acting factor

Haidong Xu, Bolin Ning, Fang Mu, Hui Li, Ning Wang. Advances of functional consequences and regulation mechanisms of alternative cleavage and polyadenylation[J]. Hereditas(Beijing), 2021, 43(1): 4-15.

Figures/Tables 2

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