肿瘤液态活检的研究进展及其临床应用

doi:10.16288/j.yczz.16-386

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (3): 220-231.doi: 10.16288/j.yczz.16-386

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Research progress on liquid biopsy in oncology and its clinical applications

Chen Wang^1,²(),Yanming Li^1,²,Xiangdong Fang^1,²()

1. CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
2. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2016-11-18 Revised:2017-01-19 Online:2017-03-20 Published:2017-02-23
Supported by:
the National Natural Science Foundation of China(31471115,31401160,81670109)

Abstract

Abstract:

Liquid biopsy is an emerging and promising detection tool for cancer, with the benefit of being non-invasive and convenient. It analyzes tumor-derived information in the blood or other body fluids including circulating tumour cells (CTCs), circulating tumour DNA (ctDNA) and exosomes. Nowadays, with the expansion of liquid biopsy research contents and the development of capture and detection technologies, liquid biopsy is increasingly utilized in clinical applications, promoting the development of tumor precision medicine. Here, we mainly focus on reviewing the objects and technologies about liquid biopsy, as well as its applications, development and challenges in clinical practices.

Key words: liquid biopsy, CTCs, ctDNA, NGS

Chen Wang,Yanming Li,Xiangdong Fang. Research progress on liquid biopsy in oncology and its clinical applications[J]. Hereditas(Beijing), 2017, 39(3): 220-231.

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