Hippo信号通路在肺发育、再生和疾病中的功能

doi:10.16288/j.yczz.17-056

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (7): 597-606.doi: 10.16288/j.yczz.17-056

• Review • Previous Articles Next Articles

Hippo signaling pathway in lung development, regeneration, and diseases

Siling Fu^1,²(),Wanying Zhao^1,³(),Wenjing Zhang⁴(),Hai Song⁵(),Hongbin Ji⁴(),Nan Tang¹()

1. National Institute of Biological Sciences, Beijing 102206, China
2. Graduate School of Peking Union Medical College, Beijing 100005, China
3. School of Life Science,Tsinghua University, Beijing 100084, China
4. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
5. School of Life Science, Zhejiang University, Hangzhou 310058, China

Received:2017-02-21 Revised:2017-03-22 Online:2017-07-20 Published:2017-05-31
Supported by:
the National Basic Research Program of China(2014CB850003);the National Natural Science Foundation of China(31471368);the National Science Foundation for Distinguished Young Scholars(81325015)

Abstract

Abstract:

The mammalian lung is essential for the gas exchange function between the circulation and the atmospheric environment. Lung diseases, including lung cancer, are among the leading causes of death in the modern society. Research on lung development, regeneration and cancer could provide significant insights for the development of therapeutic approaches on lung diseases. Hippo/YAP/TAZ signaling pathway regulates cell proliferation and differentiation, controls organ size, and plays an important role in response to mechanical forces. YAP/TAZ are expressed in many cell types and serve various regulatory functions in the embryonic and adult lungs. In this review, we mainly focus on the roles of Hippo/YAP/TAZ signaling pathway in embryonic lung development, regeneration and cancer. We postulate that Hippo/YAP/TAZ signaling may play potential roles in regulating the alveolar mechanics and immune responses in the lung.

Key words: Hippo signaling pathway, lung development and regeneration, lung cancer, lung fibrosis

Siling Fu,Wanying Zhao,Wenjing Zhang,Hai Song,Hongbin Ji,Nan Tang. Hippo signaling pathway in lung development, regeneration, and diseases[J]. Hereditas(Beijing), 2017, 39(7): 597-606.

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