Hippo信号通路调控免疫细胞的功能

doi:10.16288/j.yczz.17-083

[an error occurred while processing this directive]

Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (7): 650-658.doi: 10.16288/j.yczz.17-083

• Review • Previous Articles Next Articles

The functions of the Hippo signaling pathway in immune cells

Shujuan Yu(),Jing Geng(),Lanfen Chen()

School of Life Sciences, Xiamen University, Xiamen 361102, China

Received:2017-03-09 Revised:2017-04-07 Online:2017-07-20 Published:2017-06-28
Supported by:
the National Basic Research Program of China (973 Program)(2017YFA0504502,2015CB910502);the National Natural Science Foundation of China(81422018,U1405225,81372617,31600698);Major Disease Research Projects of Xiamen(3502Z20149029)

Abstract

Abstract:

The Hippo signaling pathway, first identified in Drosophila, has emerged as a critical regulator for controlling the size of organs. Activation of the Hippo signaling pathway negatively regulates the Yorkie ortholog YAP in multiple organs, important in the regulation of cell proliferation, differentiation, and apoptosis during development. The Serine/Threonine protein kinases MST1 and MST2, mammalian homologs of the Drosophila Hippo kinase, play central roles in the Hippo signaling pathway in mammals. Recent studies reveal that non-canonical Hippo signaling pathways are also involved in the regulation of various other biological processes, particularly the important roles of MST1 and MST2 kinases in immune cell activation, adhesion, migration, growth, and apoptosis. In this review, we summarize the recent advances in understanding the roles of MST1 and MST2 kinases in the regulation of the functions of T lymphocytes and innate immune cells.

Key words: Hippo signaling pathway, T cells, innate immune cells

Shujuan Yu,Jing Geng,Lanfen Chen. The functions of the Hippo signaling pathway in immune cells[J]. Hereditas(Beijing), 2017, 39(7): 650-658.

References

[1]	Harvey KF, Pfleger CM, Hariharan IK. The drosophila mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell, 2003, 114(4): 457-467.
[2]	Jia JH, Zhang WS, Wang B, Trinko R, Jiang J. The drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev, 2003, 17(20): 2514-2519.
[3]	Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev, 1995, 9(5): 534-546.
[4]	Pantalacci S, Tapon N, Léopold P. The salvador partner hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol, 2003, 5(10): 921-927.
[5]	Udan RS, Kango-Singh M, Nolo R, Tao CY, Halder G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol, 2003, 5(10): 914-920.
[6]	Wu SA, Huang JB, Dong JX, Pan DJ. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell, 2003, 114(4): 445-456.
[7]	Xu T, Wang W, Zhang S, Stewart RA, Yu W. Identifying tumor suppressors in genetic mosaics: the drosophila lats gene encodes a putative protein kinase. Development, 1995, 121(4): 1053-1063.
[8]	Creasy CL, Chernoff J. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene, 1995, 167(1-2): 303-306.
[9]	Creasy CL, Chernoff J. Cloning and characterization of a human protein kinase with homology to Ste20. J Biol Chem, 1995, 270(37): 21695-21700.
[10]	Tao WF, Zhang S, Turenchalk GS, Stewart RA, St John MAR, Chen WL, Xu T. Human homologue of the drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet, 1999, 21(2): 177-181.
[11]	Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA. Mechanism of activation of ndr (nuclear Dbf2-related) protein kinase by the hMOB1 protein. J Biol Chem, 2004, 279(34): 35228-35235.
[12]	Tapon N, Harvey KF, Bell DW, Wahrer DCR, Schiripo TA, Haber DA, Hariharan IK. salvador promotes both cell cycle exit and apoptosis in drosophila and is mutated in human cancer cell lines. Cell, 2002, 110(4): 467-478.
[13]	Sudol M. Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the yes proto-oncogene product. Oncogene, 1994, 9(8): 2145-2152.
[14]	Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. TAZ: a novel transcriptional co-activator regulated by interactions w

Metrics

Comments

www.chinagene.cn
备案号：京ICP备09063187号

The functions of the Hippo signaling pathway in immune cells

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments