MST1/2调控先天免疫的功能和机制

doi:10.16288/j.yczz.17-066

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (7): 642-649.doi: 10.16288/j.yczz.17-066

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The roles and mechanisms of MST1/2 in the innate immune response

Xin Zhou(),Weiyun Li,Hongyan Wang()

CAS Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China

Received:2017-02-28 Revised:2017-03-22 Online:2017-07-20 Published:2017-06-28
Supported by:
the National Natural Science Foundation of China(81571617, 31300723, 81671572, 31422018);the Strategic Priority Research Program of the Chinese Academy of Sciences Center for Excellence in Molecular Cell Science(XDB19000000);the Ministry of Science and Technology of China(2016YFD0500207, 2016YFC0902200)

Abstract

Abstract:

The Hippo signaling pathway regulates cell proliferation, organ size and tissue regeneration through a series of kinase cascades. MST1/2 is the mammalian orthologue of the core kinase Hippo, which is crucial for the activation of downstream signaling. Additionally, MST1/2 has been reported to play important roles in cell differentiation, morphology and cytoskeleton reorganization. Recent evidence suggests that MST1/2 is involved in the regulation of T cell adhesion, migration, homing and Treg cell maturation and functions. Interestingly, these processes are not dependent on the canonical, but a non-canonical Hippo signaling pathway. More recent studies have revealed that MST1/2 mediates the innate immune response against pathogens or viruses, especially on macrophage phagocytosis as well as cytokines and ROS production. MST1/2 is associated with various diseases, such as bacterial or viral infection, inflammation-related cancer, and atherosclerosis. In this review, we summarize recent findings on the functions of MST1/2 in the innate immune response and inflammation-related diseases.

Key words: Hippo signaling pathway, MST1/2, innate immune, macrophage, inflammation-related disease

Xin Zhou,Weiyun Li,Hongyan Wang. The roles and mechanisms of MST1/2 in the innate immune response[J]. Hereditas(Beijing), 2017, 39(7): 642-649.

References

[1]	Varelas X. The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Development, 2014, 141(8): 1614-1626.
[2]	Zhao B, Wei XM, Li WQ, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu JD, Li L, Zheng P, Ye KQ, Chinnaiyan A, Halder G, Lai ZC, Guan KL. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev, 2007, 21(21): 2747-2761.
[3]	Liu B, Zheng YG, Yin F, Yu JZ, Silverman N, Pan DJ. Toll receptor-mediated Hippo signaling controls innate immunity in Drosophila. Cell, 2016, 164(3): 406-419.
[4]	Zhang L. Control of growth and beyond: a special issue on Hippo signaling. Acta Biochim Biophys Sin (Shanghai), 2015, 47(1): 1.
[5]	Meng ZP, Moroishi T, Mottier-Pavie V, Plouffe S W, Hansen CG, Hong AW, Park HW, Mo JS, Lu WQ, Lu SC, Flores F, Yu FX, Halder G, Guan KL. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun, 2015, 6: 8357.
[6]	Wang GC, Lu X, Dey P, Deng PN, Wu CC, Jiang S, Fang ZN, Zhao K, Konaparthi R, Hua SJ, Zhang JH, Li-Ning-Tapia EM, Kapoor A, Wu CJ, Patel NB, Guo ZL, Ramamoorthy V, Tieu TN, Heffernan T, Zhao D, Shang XY, Khadka S, Hou PP, Hu BL, Jin EJ, Yao WT, Pan XL, Ding ZH, Shi YX, Li LR, Chang Q, Troncoso P, Logothetis CJ, McArthur MJ, Chin L, Wang YA, DePinho RA. Targeting YAP-dependent MDSC infiltration impairs tumor progression. Cancer Discov, 2016, 6(1): 80-95.
[7]	Yimlamai D, Christodoulou C, Galli GG, Yanger K, Pepe- Mooney B, Gurung B, Shrestha K, Cahan P, Stanger BZ, Camargo FD. Hippo pathway activity influences liver cell fate. Cell, 2014, 157(6): 1324-1338.
[8]	Harvey KF, Zhang MX, Thomas DM. The Hippo pathway and human cancer. Nat Rev Cancer, 2013, 13(4): 246-257.
[9]	Renner O, Fominaya J, Alonso S, Blanco-Aparicio C, Leal JFM, Carnero A. MST1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate. Carcinogenesis, 2007, 28(7): 1418-1425.
[10]	Bernascone I, Martin-Belmonte F. Crossroads of Wnt and Hippo in epithelial tissues. Trends Cell Biol, 2013, 23(8): 380-389.
[11]	Kim M, Jho EH. Cross-talk between Wnt/β-catenin and Hippo signaling pathways: a brief review. Bmb Rep, 2014, 47(10): 540-545.
[12]	Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang KP, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature, 2015, 519(7541): 57-62.
[13]	Ling P, Lu TJ, Yuan CJ, Lai MD. Biosignaling of mammalian Ste20-related kinases. Cell Signal, 2008, 20(7): 1237-1247.
[14]
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