RHR转录因子家族起源、功能以及进化机制的研究进展

doi:10.16288/j.yczz.20-332

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Hereditas(Beijing) ›› 2021, Vol. 43 ›› Issue (3): 215-225.doi: 10.16288/j.yczz.20-332

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Progress on the origin, function and evolutionary mechanism of RHR transcription factor family

Menggang Lv^1,²(), Aijia Liu^1,², Qingwei Li^1,²(), Peng Su^1,²()

¹ College of Life Science, Liaoning Normal University, Dalian 116081, China
² Lamprey Research Center, Liaoning Normal University, Dalian 116081, China;

Received:2020-11-25 Online:2021-03-16 Published:2021-01-29
Supported by:
the National Natural Science Foundation of China(31801973);the National Natural Science Foundation of China(31772884);Dalian Supports Innovation and Entrepreneurship Projects of High Level Talents(2019RQ126);the Chinese Major State Basic Research Development Program (973)(2013CB835304);the Marine Public Welfare Project of the State Oceanic Administration(201305016);the project of Department of Ocean and Fisheries of Liaoning Province(201805);and the Science and Technology Innovation Fund Research Project(2018J12SN079)

Abstract

Abstract:

Transcription factors are a class of proteins that regulate gene transcription and expression by binding to gene-specific sequences and play an essential role in regulating the biological activities of cells. The RHR (Rel-homology region) transcription factor family is the primary member of the IF (immunoglobulin fold) transcription factor superfamily, whose members contain the conserved Rel domain and IPT (immunoglobulin-like fold) domain. As an ancient transcription factor family, the RHR family continues differentiation on gene gain and loss through gene duplication, mutation, and silencing, accompanied with the evolution of diverse species. Natural selection has led to different rates of evolution among members of the family, and some domains of the protein family have shown unique mechanisms of evolution. However, the current reviews about the origin and differentiation of RHR family are rare. In this review, we summarize the research results on the distribution, classification, function, and evolution of the members of the RHR family in order to provide a reference and new idea for studying the evolution mechanism of the whole transcription factor family and the evolutionary relationship among species.

Key words: transcription factors, RHR family, evolution, gene duplication, homologous gene

Menggang Lv, Aijia Liu, Qingwei Li, Peng Su. Progress on the origin, function and evolutionary mechanism of RHR transcription factor family[J]. Hereditas(Beijing), 2021, 43(3): 215-225.

Figures/Tables 3

References 84

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Progress on the origin, function and evolutionary mechanism of RHR transcription factor family

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