两侧对称动物左右不对称发生机制研究进展

doi:10.16288/j.yczz.23-044

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Hereditas(Beijing) ›› 2023, Vol. 45 ›› Issue (6): 488-500.doi: 10.16288/j.yczz.23-044

• Review • Previous Articles Next Articles

Progress on the mechanism of left-right asymmetrical patterning in bilaterians

Chaofan Xing^1,²(), Mintao Wang^1,², Lei Wang^1,², Xin Shen^1,²

1. Jiangsu Key Laboratory of Marine Bioresources and Environment /Jiangsu Key Laboratory of Marine Biotechnology School of Marine Science and Fisheries, Jiangsu Ocean University, Lianyungang 222005, China
2. Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, Lianyungang 222005, China

Received:2023-02-28 Revised:2023-05-16 Online:2023-06-20 Published:2023-05-29
Contact: Xing Chaofan E-mail:chaofanxing2021@163.com
Supported by:
National Natural Science Foundation of China(32200411);Natural Science Foundation of the Jiangsu Higher Education Institutions(22KJB180014);Priority Academic Program Development Fund of Jiangsu Higher Education Institutions(22KJB180014)

Abstract

Abstract:

Left-right asymmetry is an essential feature in bilateral animals. The mechanism underlying the left-right asymmetrical organ morphogenesis is a central question in developmental biology. Studies in vertebrates show that left-right asymmetry formation needs three essential steps: the initial left-right symmetry breaking, the left-right asymmetrical gene expression, and the left-right asymmetrical organ morphogenesis. Many vertebrates use cilia to produce directional fluid flow to break symmetry during embryonic development, asymmetric Nodal-Pitx2 signaling to pattern the left-right asymmetry, and Pitx2 and other genes to control the morphogenesis of asymmetrical organs. In invertebrates, there are left-right mechanisms independent of cilia and even others more different from that of vertebrates. In this review, we summarize the major steps and relevant molecular mechanisms of left-right asymmetric development in vertebrates and invertebrates, aiming to provide a reference for the understanding of the origin and evolution of the left-right developmental mechanism.

Key words: bilaterians, left-right asymmetry, development, evolutionary origin

Chaofan Xing, Mintao Wang, Lei Wang, Xin Shen. Progress on the mechanism of left-right asymmetrical patterning in bilaterians[J]. Hereditas(Beijing), 2023, 45(6): 488-500.

Figures/Tables 4

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Table 1

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分类	物种	Dand5	Nodal	Vg1	Lefty	Pitx	BMP信号
脊椎动物	小鼠 (Mus musculus)	参与	参与	参与	参与	参与	参与
	鸡 (Gallus gallus)	参与	参与	参与	参与	参与	参与
	非洲爪蟾 (Xenopus laevis)	参与	参与	参与	参与	参与	参与
	斑马鱼 (Danio rerio)	参与	参与	参与	参与	不参与	参与
无脊椎动物	住囊虫 (Oikopleura)	未知	不存在	未知	未知	不参与	参与
	海鞘 (Ascidiacea)	未知	参与	未知	未知	参与	未知
	文昌鱼 (Branchiostoma)	参与	参与	参与	参与	参与	参与
	海胆 (Echinoidea)	未知	参与	未知	参与	参与	参与
	果蝇 (Drosophila)	未知	不存在	未知	未知	不存在	未知
	腹足类 (Snails)	未知	参与	未知	未知	参与	参与
	线虫 (Nematoda)	未知	不存在	未知	未知	不存在	未知
	水螅 (Hydra)	未知	参与	未知	未知	参与	未知

Progress on the mechanism of left-right asymmetrical patterning in bilaterians

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