微RNA通过调节上皮间质转化影响肿瘤转移

doi:10.3724/SP.J.1005.2014.0637

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HEREDITAS(Beijing) ›› 2014, Vol. 36 ›› Issue (7): 637-645.doi: 10.3724/SP.J.1005.2014.0637

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MicroRNAs affect tumor metastasis through regulating epithelial- mesenchymal transition

Lihua Yang^{1, 2}, Xingkai Shen¹, Jingqiu Li^{1, 2}, Jie Yang^{1, 2}, Yanping Le^{1, 2}, Zhaohui Gong^{1, 2}

1. Institute of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, China;
2. Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China

Received:2014-01-16 Online:2014-07-20 Published:2014-06-23

Abstract

Abstract: Distant metastasis of tumor cell is a series of continuous, selectable cascades of events regulated by multiple factors and genes. Epithelial-mesenchymal transition (EMT) is a critical step during cancer metastasis. However, the mechanism of EMT in tumor is not yet fully elucidated. MicroRNAs (miRNAs) are a class of non-coding small endogenous RNAs that negatively regulate EMT-related genes at the post-transcriptional level and play critical roles in cancer metastasis. This review mainly focuses on the topics that include the relationship of EMT and tumor metastasis, transcription factors involved in EMT, and the effect of miRNAs on tumor metastasis by targeting the EMT-related transcription factors.

Key words: microRNAs, tumor metastasis, epithelial-mesenchymal transition

Lihua Yang, Xingkai Shen, Jingqiu Li, Jie Yang, Yanping Le, Zhaohui Gong. MicroRNAs affect tumor metastasis through regulating epithelial- mesenchymal transition[J]. HEREDITAS(Beijing), 2014, 36(7): 637-645.

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MicroRNAs affect tumor metastasis through regulating epithelial- mesenchymal transition

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