miR126功能的多效性与先天性免疫

doi:10.3724/SP.J.1005.2014.0631

[an error occurred while processing this directive]

HEREDITAS(Beijing) ›› 2014, Vol. 36 ›› Issue (7): 631-636.doi: 10.3724/SP.J.1005.2014.0631

• Reviews • Previous Articles Next Articles

Functions of miR126 and innate immune response

Yu Bai, Wenyun Lu, Ning Han, Hongwu Bian, Muyuan Zhu

Institution of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China

Received:2014-02-26 Online:2014-07-20 Published:2014-06-23

Abstract

Abstract: MicroRNAs (miRNAs) are endogenous non-coding small RNAs that negatively regulate gene expression at the post-transcriptional level by base pairing with target mRNAs. Many miRNAs have been proven to regulate a broad range of processes, including proliferation, differentiation, development and apoptosis. miR126 is encoded by intron 7 of the EGF- like domain 7 (Egfl7) gene and highly expressed in human endothelial cells (ECs) and plasmacytoid dendritic cells (pDCs). Based on the current knowledge, miR126 is involved in angiogenesis and cancer. Also miR126 is the first miRNA which has been reported to involve in preconditioning the responsiveness of the host to pathogen infection in the steady state. This implicated that miR126 may be the potential therapeutic target for cancer and autoimmune diseases. In this review, we summarize the functions of miR126 in angiogenesis and cancer, and emphasize its relationship with innate immune response.

Key words: miR126, angiogenesis, cancer, innate immune

Yu Bai, Wenyun Lu, Ning Han, Hongwu Bian, Muyuan Zhu. Functions of miR126 and innate immune response[J]. HEREDITAS(Beijing), 2014, 36(7): 631-636.

References

[1] RC, Feinbaum RL, Ambros V. The C . elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell , 1993, 75(5): 843-854.
[2] B, Arif MA, Seumel GI, Ossowski S, Weigel D, Reski R, Frank W. Transcriptional control of gene expression by microRNAs. Cell , 2010, 140(1): 111-122.
[3] KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. c-Myc-regulated microRNAs modulate E2F1 expression. Nature , 2005, 435(7043): 839-843.
[4] EV, Zhang J, Carrasco MA, Maniatis T. The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell , 2007, 27(3): 435-448.
[5] A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, Wojcik SE, Aqeilan RI, Zupo S, Dono M, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA , 2005, 102(39): 13944-13949.
[6] GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer , 2006, 6(11): 857-866.
[7] D, Boldin MP, O'Connell RM, Rao DS, Taganov KD. MicroRNAs: new regulators of immune cell development and function. Nat Immunol , 2008, 9(8): 839-845.
[8] M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T. Identification of Tissue-Specific MicroRNAs from mouse. Curr Biol , 2002, 12(9): 735-739.
[9] S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, Olson EN. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev C ell , 2008, 15(2): 261-271.
[10] JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D. miR-126 regulates angiogenic signaling and vascular integrity. Dev C ell , 2008, 15(2): 272-284.
[11] L, Leahy A, Chitnis S, Koschnick S, Fitch MJ, Fallon JT, Loskutoff D, Taubman MB, Stuhlmann H. EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury. Am J P a thol , 2005, 167(1): 275-284.
[12] P. Angiogenesis in health and disease. Nat M ed , 2003, 9(6): 653-660.
[13] C, Sah JF, Beard L, Willson JK, Markowitz SD, Guda K. The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer , 2008, 47(11): 939-946.
[14] Y, Negishi Y, Nakamura A, Ukai S, Ooaku K, Oda Y, Sugimoto K, Moriyasu F, Takagi N, Suzuki R, Maruyama K, Aramaki Y. Systemic delivery of miR-126 by miRNA-loaded Bubble liposomes for the treatment of hindlimb ischemia. Sci Rep , 2014, 4: 3883.
[15] 杨建香, 李真, 刘红云, 刘建新. 乳腺发育及泌乳相关miRNA研究进展. 遗传, 2013, 35(6): 695-702.
[16] SF, Alarcon C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J. Endogenous human microRNAs that suppress breast cancer metastasis. Nature , 2008, 451(7175): 147-152.
[17] N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, Calin GA, Liu CG, Croce CM, Harris CC. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell , 2006, 9(3): 189-198.
[18] R, Chen X, Yu Y, Su L, Yu B, Li J, Cai Q, Yan M, Liu B, Zhu Z. miR-126 functions as a tumour suppressor in human gastric cancer. Cancer Lett , 2010, 298(1): 50-63.
[19] Y, Friedman JM, Chihara Y, Egger G, Chuang JC, Liang G. Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun , 2009, 379(3): 726-731.
[20] X, Tang S, Le SY, Lu R, Rader JS, Meyers C, Zheng ZM. Aberrant expression of oncogenic and tumor- suppressive microRNAs in cervical cancer is required for cancer cell growth. PloS O NE , 2008, 3(7): e2557.
[21] B, Peng XC, Zheng XL, Wang J, Qin YW. MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo . Lung C ancer , 2009, 66(2): 169-175.
[22] RB,

Metrics

Comments

www.chinagene.cn
备案号：京ICP备09063187号

Functions of miR126 and innate immune response

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Qingyu Sun, Yang Zhou, Lijuan Du, Mengke Zhang, Jiale Wang, Yuanyuan Ren, Fang Liu. Analysis between macrophage-related genes with prognosis and tumor microenvironment in non-small cell lung cancer [J]. Hereditas(Beijing), 2023, 45(8): 684-699.
[2]	Weize Kong, Yishi Liu, Xiaodong Gao, Morihisa Fujita. Comprehensive in silico analysis of glycosylphosphatidylinositol- anchored protein (GPI-AP) related genes expression profiles in human normal and cancer tissues [J]. Hereditas(Beijing), 2023, 45(8): 669-683.
[3]	Chunhui Ma, Haixu Hu, Lijuan Zhang, Yi Liu, Tianyi Liu. Establishment and verification of a digital PCR assay for the detection of CK19 expression in quantitative analysis of circulating tumor cell [J]. Hereditas(Beijing), 2023, 45(3): 250-260.
[4]	Dong Chang, Xiangxiang Liu, Rui Liu, Jianwei Sun. The role and regulatory mechanism of FSCN1 in breast tumorigenesis and progression [J]. Hereditas(Beijing), 2023, 45(2): 115-127.
[5]	Sihan Qi, Qilin Wang, Junyou Zhang, Qian Liu, Chunyan Li. The regulatory mechanisms by enhancers during cancer initiation and progression [J]. Hereditas(Beijing), 2022, 44(4): 275-288.
[6]	Changgui Lei, Xueyuan Jia, Wenjing Sun. Establish six-gene prognostic model for glioblastoma based on multi-omics data of TCGA database [J]. Hereditas(Beijing), 2021, 43(7): 665-679.
[7]	Youhong Chen, Wenhao Yang, Chao Ni. Using esophagus organoid to explore the role of c-Myc in esophageal cancer initiation [J]. Hereditas(Beijing), 2021, 43(6): 601-614.
[8]	Yige Li, Dandan Zhang. Progress on functional mechanisms of colorectal cancer causal SNPs in post-GWAS [J]. Hereditas(Beijing), 2021, 43(3): 203-214.
[9]	Yajie Wang, Shuangshuang Wu, Jiang Chu, Xiangyang Kong. Lung microbiome mediates the progression from chronic obstructive pulmonary disease to lung cancer through inflammation [J]. Hereditas(Beijing), 2021, 43(1): 30-39.
[10]	Qian Liu, Chunyan Li. The identification of enhancers and its application in cancer studies [J]. Hereditas(Beijing), 2020, 42(9): 817-831.
[11]	Qin Lili, Li Yijian, Liang Zhaorui, Dai Lei, Li Wenhui, Chen Chao, Huang Yaling, Zhang Le, Liu Songming, Qiu Si, Ge Yuping, Peng Wenting, Lin Xinxin, Zhang Xiuqing, Dong Xuan, Li Bo. A method of screening highly common neoantigens with immunogenicity in colorectal cancer based on public somatic mutation library [J]. Hereditas(Beijing), 2020, 42(6): 599-612.
[12]	Huxing Chen, Lei Xu, Jing Li, Zheng Guo, Lu Ao. The development of a general drug resistance score model based on MIC₅₀ related gene pairs in colorectal cancer cell lines [J]. Hereditas(Beijing), 2020, 42(6): 577-585.
[13]	Qiang Zhang, Mingliang Gu. Single-cell sequencing and its application in breast cancer [J]. Hereditas(Beijing), 2020, 42(3): 250-268.
[14]	Xinyuan Wang, Yu Zhang, Nan Yang, He Cheng, Yujie Sun. DNMT3a mediates paclitaxel-induced abnormal expression of LINE-1 by increasing the intragenic methylation [J]. Hereditas(Beijing), 2020, 42(1): 100-111.
[15]	Huanzi Lu,Dikan Wang,Zhi Wang. Correlation analysis of the prognosis of HPV positive oropharyngeal cancer patients with T cell infiltration and neoantigen load [J]. Hereditas(Beijing), 2019, 41(8): 725-735.