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HEREDITAS(Beijing) ›› 2015, Vol. 37 ›› Issue (2): 111-120.doi: 10.16288/j.yczz.14-283

• Reviews •     Next Articles

The relationship of SIRT3 with cellular metabolism and cardiovascular diseases

Lijuan Cao,Xinhe Liu,Qing Zha,Qian Song,Ke Yang,Yan Liu   

  1. Department of Cardiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
  • Received:2014-08-26 Online:2015-02-20 Published:2015-01-19

Abstract: Protein deacetylases play an extremely crucial role in cellular biological processes and have been categorized into four families (HDACⅠ, HDACⅡ, HDACⅢ and HDACⅣ) in human. Of them, HDACⅢ, also known as the Sir2 (Silent information regulator 2) family, contains seven members, SIRT1-7, each exhibiting different cellular localization and biological function. As a major mitochondrial deacetylase, SIRT3 not only modulates cellular metabolism, but also plays important roles in apoptosis, tumor growth, aging and a number of other diseases. In this review, we summarize recent findings related to SIRT3 with an emphasis on its biological functions in regulating cell metabolism and its possible roles in cardiovascular diseases.

Key words: SIRT3, HDAC, cell metabolism, cardiovascular diseases