脂蛋白酯酶基因PvuⅡ多态与中国人高脂血症和冠心病的Meta分析

doi:10.3724/SP.J.1005.2010.01031

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (10): 1031-1036.doi: 10.3724/SP.J.1005.2010.01031

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Meta-analysis of LPL PvuⅡ polymorphism with hyperlipoidemia and coronary heart disease in the Chinese population

CUI Lu-Lu, WANG Min, HUANG Qing-Yang

Hubei Key Lab of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan 430079, China

Received:2010-01-16 Revised:2010-03-01 Online:2010-10-20 Published:2010-10-20
Contact: HUANG Qing-Yang E-mail:huangqy@mail.ccnu.edu.cn

Abstract

Abstract: Multiple studies reported the association of LPL PvuⅡpolymorphism (rs285) with hyperlipoidemia and coronary heart disease in the Chinese population; however, the sample sizes of these studies were small (119-647) and the results were not consistent. A Meta-analysis was undertaken to evaluate the role of LPL PvuⅡpolymorphism in hyperlipoidemia and coronary heart disease in Chinese. A total of 11 case-control studies were collected. Among them, 6 studies on hyperlipoidemia contained 943 cases and 1,093 controls, and 5 studies on coronary heart disease contained 821 cases and 727 controls. No significant publication bias was found and significant heterogeneity between these studies was observed. The results of Meta-analysis indicated that the allele P+ increased the risk of hyperlipoidemia (OR=1.36, 95%CI 1.07~1.73, P=0.011), and no evidence of association (P=0.755) was found for coronary heart disease. Our study suggested that the LPL PvuⅡpolymorphism was significantly associated with hyperlipoidemia but not with coronary heart disease in the Chinese population.

Key words: lipoprotein lipase, polymorphism, hyperlipoidemia, coronary heart disease, meta-analysis

References

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Meta-analysis of LPL PvuⅡ polymorphism with hyperlipoidemia and coronary heart disease in the Chinese population

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