防御素的生物学特性及其抗病基因工程

doi:10.3724/SP.J.1005.2011.00512

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HEREDITAS ›› 2011, Vol. 33 ›› Issue (5): 512-519.doi: 10.3724/SP.J.1005.2011.00512

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Biological characteristics of defensin and its disease-resistance genetic engineering

FU Lan-Bao^{1, 2}, YU Jia-Lin¹, LIU Wei-Hua²

1. The State Key Laboratory for Agro-biotechnology, China Agricultural University, Beijing 100193, China 2. National Key Facilities for Crop Gene Resources and Genetic Improvement/Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China

Received:2010-11-01 Revised:2011-01-27 Online:2011-05-20 Published:2011-05-25
Contact: LIU Wei-Hua E-mail:liuwh@caas.net.cn

Abstract

Abstract: Defensin is a kind of cysteine-rich small peptide, which has a broad spectrum of resistance to bacteria with a special resistance mechanism. So far, a large number of studies on defensins have been reported, and the different types of defensins have been isolated from various organisms. A broad prospect of application on defensins has been displayed both in genetic engineering and medicine field. This article reviewed the classification and the biological characteristics of defensins, including mammalian α-, β-, θ-defensins, insect defensins, and plant defensins. The molecular structures, antibacterial activities, and antibacterial mechanisms of these definsins were summarized. The two mechanisms of de-fensin, including independent membrane mechanism and targeting of intracellular compounds by defensins, are ex-pounded. This paper also summarized the researches on isolation and expression of defensin genes and disease resistance genetic engineering of mammal and plant defensins. A prospect of the future applications of defensin both in biophar-maceutical sciences and plant disease resistance genetic engineering was discussed.

Key words: defensin, disease resistance, genetic engineering

FU La-Bao, XU Jia-Lin, LIU Wei-Hua. Biological characteristics of defensin and its disease-resistance genetic engineering[J]. HEREDITAS, 2011, 33(5): 512-519.

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Biological characteristics of defensin and its disease-resistance genetic engineering

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