MicroRNA对皮肤毛囊发育的调控机制

doi:10.3724/SP.J.1005.2014.0655

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HEREDITAS(Beijing) ›› 2014, Vol. 36 ›› Issue (7): 655-660.doi: 10.3724/SP.J.1005.2014.0655

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The regulatory mechanism of microRNAs in skin and hair follicle development

Lu Zhang, Yanjun Zhang, Rui Su, Ruijun Wang, Jinquan Li

Inner Mongolia Key Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China

Received:2013-12-03 Online:2014-07-20 Published:2014-06-23

Abstract

Abstract: MicroRNAs (miRNAs) are an emerging class of regulators that control post-transcriptional processes, and could be potential targets for drug in pathology and potential sites of phenotypic regulation. Although some functions of miRNAs have been known, the regulatory mechanism of miRNAs in skin and hair follicle development remains unclear. High throughput sequencing provides more accurate and rapid method for identification of miRNAs. It has been found that some miRNAs affect the cell differentiation and proliferation of skin and hair follicles, and their target genes play important roles in the periodic growth of hair follicles. In this review, we summarize the recent achievements of the regulatory mechanism of miRNAs in the skin follicles and provide useful clues for further study on miRNA regulation in hair follicle growth of cashmere goat.

Key words: microRNA, skin, hair follicle, regulatory mechanism

Lu Zhang, Yanjun Zhang, Rui Su, Ruijun Wang, Jinquan Li. The regulatory mechanism of microRNAs in skin and hair follicle development[J]. HEREDITAS(Beijing), 2014, 36(7): 655-660.

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The regulatory mechanism of microRNAs in skin and hair follicle development

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