质粒介导的黏菌素耐药基因mcr-1研究进展

doi:10.16288/j.yczz.16-331

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (2): 110-126.doi: 10.16288/j.yczz.16-331

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Research progress on the plasmid-mediated colistin resistance gene mcr-1

Lingxian Yi¹(),Yiyun Liu¹,Renjie Wu¹,Zisen Liang¹,Jian-Hua Liu¹()

1. College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China

Received:2016-09-29 Revised:2016-12-11 Online:2017-02-09 Published:2017-01-24
Supported by:
the National Key Basic Research Program of China (973 Program)(2013CB127200);the National Natural Science Foundation of China(81661138002)

Abstract

Abstract:

mcr-1, the first plasmid-mediated colistin-resistance gene, can mediate polymyxin resistance and be transferred horizontally via plasmids. Many studies have confirmed its distribution via epidemic plasmids (IncI2, IncX4, IncHI2, etc.), as well as mobile genetic elements, among Enterobacteriaceae isolated from animals, humans, and the environment in 35 countries. These studies provide the basis of understanding the complicated mechanism of colistin resistance mediated by MCR-1 and its global dissemination and epidemic properties, and also enrich antimicrobial resistance mechanisms. Here, we review the latest advances in the prevalence, resistance mechanism, transfer mechanism, and genetic environments of mcr-1 in isolates recovered from various samples worldwide. Finally, we discuss the clinical risk and the corresponding solutions, aiming to provide a basis for researchers and clinical scientists to face the serious challenge of antimicrobial resistance together.

Key words: plasmid, colistin, Enterobacteriaceae, resistance, mcr-1

Lingxian Yi,Yiyun Liu,Renjie Wu,Zisen Liang,Jian-Hua Liu. Research progress on the plasmid-mediated colistin resistance gene mcr-1[J]. Hereditas(Beijing), 2017, 39(2): 110-126.

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