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Hereditas(Beijing) ›› 2018, Vol. 40 ›› Issue (10): 825-840.doi: 10.16288/j.yczz.18-209

• Reviews • Previous Articles     Next Articles

Historical review of reprogramming and pluripotent stem cell research in China

Lan Kang2,3(), Jiayu Chen1,2(), Shaorong Gao1,2()   

  1. 1. Center of Translational Medicine, First Maternal and Child Health Care Hospital, Tongji University, Shanghai 201104, China
    2. School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
    3. Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University,Shanghai 200123, China
  • Received:2018-07-20 Revised:2018-08-30 Online:2018-10-20 Published:2018-09-11
  • Supported by:
    the National Key R&D program of China(2016YFA0100400);the National Natural Science Foundation of China(31721003);the National Natural Science Foundation of China(81630035);the National Natural Science Foundation of China(31430056);the National Natural Science Foundation of China(31871489);the National Natural Science Foundation of China(31871446)

Abstract:

The research of stem cell field has developed rapidly in recent decades. With the enhancing of China's economic power, the strength of scientific research is steadily increasing, and the stem cell research even has reached international advanced level. Here, we make a historical review of important research in China, focusing on somatic cell nuclear transfer, induced pluripotent stem cells, haploid pluripotent stem cells and early embryo development. The fast development of single cell sequencing will greatly help the understanding of various development process, and the stem cell clinical application will blossom in China in the future.

Key words: reprogramming, somatic cell nuclear transfer, induced pluripotent stem cells, haploid pluripotent stem cells, single cell sequencing