哺乳动物体细胞核移植表观遗传重编程研究进展

doi:10.16288/j.yczz.19-193

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (12): 1099-1109.doi: 10.16288/j.yczz.19-193

• Review • Previous Articles Next Articles

Advances in epigenetic reprogramming of somatic cells nuclear transfer in mammals

Xuqiong Yang, Zhenfang Wu, Zicong Li()

National Engineering Research Center for Swine Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China

Received:2019-07-03 Revised:2019-10-07 Online:2019-12-20 Published:2019-11-18
Contact: Li Zicong E-mail:lizicongcong@163.com
Supported by:
Supported by the National Natural Science Foundation of China No(31772554)

Abstract

Abstract:

Somatic cell nuclear transfer (SCNT) is the only reproductive engineering technique that can confer genomic totipotency on somatic cell. SCNT is of great significance for animal germplasm conservation, animal husbandry development, and biomedical research. Although many research advances have been made in this technology, the developmental rate of SCNT mammalian embryos is very low, which seriously limits the application of SCNT in animal husbandry and biomedicine. The primary reason for the low efficiency of cloned embryos is somatic cell reprogramming errors or incomplete reprogramming. These errors or incompleteness present as the abnormal expression of imprinted gene Xist, abnormal DNA methylation, and abnormal histone modification. In this review, we summarize the main factors that influence the low development efficiency of mammalian cloned embryos to provide theoretical reference for the research and practice of improving somatic cell cloning efficiency.

Key words: somatic cell nuclear transfer (SCNT), Xist, DNA methylation, histone modification

Xuqiong Yang, Zhenfang Wu, Zicong Li. Advances in epigenetic reprogramming of somatic cells nuclear transfer in mammals[J]. Hereditas(Beijing), 2019, 41(12): 1099-1109.

Figures/Tables 2

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SCNT胚胎发育效率^{[44,45,47,50,94]}		影响SCNT胚胎发育效率的表观遗传重编程因素	对策	结果
体外(囊胚率)	体内(出生率)	影响SCNT胚胎发育效率的表观遗传重编程因素	对策	结果
15% ~	1%~5%	Xist	KO-Xist;注射siRNA	克隆小鼠出生率提高8~9倍^[8]; 克隆小鼠囊胚率以及出生率提高10倍^[9];克隆猪出生率提高6.9倍^[64]
		DNA甲基化	抑制DNMT	克隆小鼠出生率提高5倍^[75]
		组蛋白乙酰化水平	添加HDACi药物	克隆猪囊胚率提高2倍^[81]; 克隆小鼠囊胚率提高5~10倍^[80]
		H3K9me3	注射Kdm4d或联合KO-Xist; 联合注射Kdm4b和Kdm5b	克隆小鼠出生率提高13~16倍^[74]; 克隆小鼠囊胚率达95%^[10]
		H3K27me3	注射Kdm6a	克隆小鼠囊胚率提高2倍^[95]

Advances in epigenetic reprogramming of somatic cells nuclear transfer in mammals

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