环境因素所致印迹基因改变与子代器官发育

doi:10.16288/j.yczz.21-302

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Hereditas(Beijing) ›› 2022, Vol. 44 ›› Issue (2): 107-116.doi: 10.16288/j.yczz.21-302

• Review • Previous Articles Next Articles

Alteration of imprinted genes and offspring organ development caused by environmental factors

Hui Qu¹(), Yi Liu¹, Yawen Chen¹, Hui Wang^1,²()

1. Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China
2. Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Wuhan 430071, China

Received:2021-10-01 Revised:2021-12-21 Online:2022-02-20 Published:2021-12-22
Contact: Wang Hui E-mail:1937211743@qq.com;wanghui19@whu.edu.cn
Supported by:
Supported by the Key Project of National Key R&D Program of China No(2020YFA0803900)

Abstract

Abstract:

Imprinted genes are a special subset of about 100 genes, which are mainly expressed in the form of parental monoallelic genes, and play important roles in the growth and development of embryos. In recent years, it has been found that epigenetic modification of imprinted genes induced by environmental factors can cause fetal multi-organ dysplasia and even susceptibility to multiple diseases in adulthood, which also exhibit multi-generational inheritance. In this review, we summarize the effects of expression changes of imprinted genes on ontogenetic development and organ functions in late stage of life, and propose that abnormal epigenetic modification and expression of imprinted genes caused by environmental deleterious factors are important mechanisms for explaining the multi-organ dysplasia in offspring. Such mechanisms are greatly significant for understanding the phenotypic changes caused by alteration of imprinted gene expression during ontogeny and exploring early prevention and treatment strategies of diseases.

Key words: imprinted genes, environmental factors, regulatory mechanisms of imprinted genes, epigenetic modification, organ development

Hui Qu, Yi Liu, Yawen Chen, Hui Wang. Alteration of imprinted genes and offspring organ development caused by environmental factors[J]. Hereditas(Beijing), 2022, 44(2): 107-116.

Figures/Tables 3

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环境因素	分类	外源物	印迹基因	影响模式	参考文献
外源性因素	化学因素	酒精	Snrpn	甲基化降低	[28]
	化学因素	TCDD	H19/IGF2	表达下调	[29]
	物理因素	X射线	H19	甲基化模式改变	[30]
	生物因素	直肠弯曲杆菌	IGF2	表达下调	[14]
	ART	体外培养	Peg3	甲基化降低	[31]
	ART	低温保存	IGF2R/Plagl1/ H19	甲基化及表达改变	[32]
亲代因素	疾病状况	母体孕期先兆子痫	Phlda2	表达上调	[33]
	疾病状况	母体产前抑郁症	Peg3	表达下调	[34]
	疾病状况	母体孕期PCOS	H19	表达上调	[35]
	疾病状况	父体肥胖	Mest/Peg3	甲基化降低	[36]
	应激	父体慢性心理应激	Sfmbt2	表达下调	[37]

Alteration of imprinted genes and offspring organ development caused by environmental factors

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