MicroRNA促进基因表达研究进展

doi:10.16288/j.yczz.24-374

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Hereditas(Beijing) ›› 2025, Vol. 47 ›› Issue (7): 729-741.doi: 10.16288/j.yczz.24-374

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Advances in microRNA promoting gene expression

Xiao Zhang(), Yan Yu, Yong Ning, Qiwen Hong, Huaiping Shi()

College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China

Received:2024-12-30 Revised:2025-02-28 Online:2025-04-23 Published:2025-04-23
Contact: Huaiping Shi E-mail:zhangzexiao@nwafu.edu.cn;huaipingshi@nwafu.edu.cn
Supported by:
National Key Research and Development Plan of China(2021YFD1600704);National Key Research and Development Plan of China(2022YFD1300200);National Natural Science Foundation of China(32272828)

Abstract

Abstract:

MicroRNAs (miRNAs) are a class of endogenous, single-stranded, noncoding RNAs ranging from 20~24 nucleotides in length. Traditionally, miRNAs are considered to inhibit mRNA translation or promote mRNA degradation, thereby exerting a negative regulatory effect on gene expression by binding to the 3′ untranslated region (UTR) in the cytoplasm. However, this framework cannot fully explain the observed positive roles of certain miRNAs in gene regulation. Recent studies have identified mechanisms such as enhancer- and promoter-mediated transcriptional activation, as well as UTR-mediated translational activation, as key processes underlying the positive regulation of gene expression by miRNAs. Additionally, the subcellular distribution of miRNAs and specific physiological conditions can influence their functions. In this review, we summarize the biological characteristics and functions of miRNAs, with the goal of providing insights for future research in this field.

Key words: miRNAs, target gene, activation

Xiao Zhang, Yan Yu, Yong Ning, Qiwen Hong, Huaiping Shi. Advances in microRNA promoting gene expression[J]. Hereditas(Beijing), 2025, 47(7): 729-741.

Figures/Tables 4

Table 1

Table 2

Statistical results of miRNAs that promote gene expression via promoter"

名称	靶向区域(相距转录起始位点)	效应元件	生理效应	参考文献
has-miR-373	CSDC2(-787/-763)	启动子	‒	[5]
has-miR-373	CDH1(-645/-622)	启动子	‒	[5]
mmu-miR-744	Ccnb1(-192/-171)	启动子	抑制细胞增殖，诱导染色质不稳定性	[27]
mmu-miR-1186	Ccnb1(-699/-678)	启动子	抑制细胞增殖，诱导染色质不稳定性	[27]
has-miR-558	HPSE(-2332/-2314)	启动子	促进NB细胞生长、侵袭、转移和血管生成	[28]
has-miR-324-3p	RelA(-66/-45)	启动子	诱导神经元细胞系凋亡	[29]
has-miR-589	COX-2(-53/-37)	启动子	‒	[30]
	COX-2(-34/-14)	启动子
	PLA2G4F(/)	启动子
has-miR-1180	CDKN1A(-397/-379)	启动子	抑制膀胱癌和肾癌细胞增殖，诱导细胞凋亡和衰老	[31]
has-miR-1236	CDKN1A(-243/-226)	启动子	抑制膀胱癌和肾癌细胞增殖，诱导细胞凋亡和衰老	[31]
has-miR-6734	CDKN1A(-322/-304)	启动子	抑制结肠癌细胞系细胞增殖，诱导细胞周期阻滞	[32]
has-miR-124	CDKN1B(-545/-533)	启动子	抑制乳腺癌卵巢癌细胞增殖、迁移和侵袭，诱导细胞周期停滞	[33]
has-miR-877-3p	CDKN2A(-320/-299)	启动子	抑制膀胱癌细胞增殖，诱导细胞周期停滞	[34]
has-miR-551-3p	STAT3(-530/-503)	启动子		[35]
has-miR-143/145	SOX2(-1302/-1297)	启动子	缓解雌激素缺乏型骨质流失	[36]
has-miR-34a	ZMYND10(-539/-341) (-98/-83)**	启动子	‒	[37]
hsa-miR-552-3p	FXR(-1107/-1102)	启动子	改善糖脂代谢紊乱	[38]
has-miR-31	CD44(-890/-865)	启动子	提高哮喘相关细胞因子	[39]
mmu-miR-320	CD36(-553/-521)	启动子	加剧糖尿病诱导的心功能障碍	[40]
miR-H3	HIV-1	启动子(TATA盒)	激活HIV病毒转录	[44]
has-miR-205	IL24(-127/-107)	启动子	促进前列腺癌细胞凋亡	[41]
has-miR-205	IL32(-631/-610)	启动子	促进前列腺癌细胞凋亡	[41]
has-let-7i	IL2(201/222)	启动子(TATA盒)	‒	[45]
has-miR-138	INS(-42/-18)	启动子(TATA盒)
has-miR-92a	CALCA(-41/-17)	启动子(TATA盒)
has-let-7c	H4A1(/)	启动子(TATA盒)
has-miR-181d	MYC(-204/-175)	启动子(TATA盒)

Table 2

Table 3

Fig. 1

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名称	靶基因	“增强子-靶基因” 距离	参考文献
has-miR-24-1	FBP1	482.88K	[21]
	FANCC	13.03K
	KDM6B	283.33K
	LSMD1	305.80K
	CYB5D1	307.12K
has-miR-26a-1	ITGA9	517.26K	[21]
	CTDSPL*	107.52K
	VILL	18.57K
has-miR-1246	MTX2	331.53K	[23]
	HNRNPA3	611.81K
	HOXD3	448.45K
	NFE2L2	629.32K
	MMP1	70.00K
has-miR-3179-2	ABCC6	150.59K	[21]
has-miR-3179-2	PKD1P1	9.97K	[21]
chi-miR-193b-3p	MKL2	368.45K	[25]
	PARN	112.35K
	BFAR	311.27K
hsa-miR-451a	KDM7A**	28.22K	[24]
has-miR-339	GPER1	64.18K	[21,22]

名称	靶向区域(相距起始密码子)	效应元件	生理效应	参考文献
has-miR369-3	TNF-α(2,258/2,291)	3′UTR (ARE)	细胞周期停滞	[6]
has-miR-93-5p	MAP3K2(35,816/35,822)	3′UTR	促进HCC细胞增殖、迁移和侵袭	[51]
has-miR-124	PTBP2(91,830/91,849)(92,569/92,595)	3′UTR	促进神经元功能成熟	[53]
has-MIR-G-1	TMED5(27,557/27,581)	3′UTR	促进细胞增殖、迁移、侵袭和EMT进展	[54]
has-MIR-G-1	LMNB1(59,085/59,094)	3′UTR	促进DNA 损伤修复	[54]
chi-miR-193b-3p	IGF2BP1(39,568/39,583)	3′UTR	促进肌肉发育	[25]
has-miR-483-5p	IGF2(-3,716/-3,214)	5′UTR	促进癌变	[55]
has-miR-122	HCV-N(1B)(-329/-313)	5′NCR	促进丙肝病毒复制	[15]
mmu-miR-10-a	RPS16(-54/-26)	5′UTR	诱导致癌转化	[16]

Advances in microRNA promoting gene expression

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