可翻译环状RNA研究进展

doi:10.16288/j.yczz.25-153

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可翻译环状RNA研究进展

邹光福¹，周敏^{1, 2}，黄川¹

1. 重庆大学生命科学学院，重庆401331 2. 重庆医科大学附属妇女儿童医院（重庆市妇幼保健院）妇产科，重庆401147

收稿日期:2025-07-12 修回日期:2025-09-02 接受日期:2025-10-11 发布日期:2025-10-11
基金资助:
国家自然科学基金项目(编号：32270601，32070633，32570667)，中华人民共和国教育部重大人才项目（编号：Q2024230），重庆市自然科学基金项目（编号：CSTB2024NSCQ-MSX0710，cstc2022ycjh-bgzxm0140），中央高校基础研究经费（编号：2024IAIS-QN006）和重庆市医学青年拔尖人才项目（编号：YXQN2025071）资助

Advances in translatable circular RNAs

Guangfu Zou¹, Min Zhou^{1, 2}, Chuan Huang¹

1. School of Life Sciences, Chongqing University, Chongqing 401331, China

2. Department of Obstetrics and Gynecology, Women and Children’s Hospital of Chongqing Medical University (Chongqing Health Center for Women and Children), Chongqing 401147, China

Received:2025-07-12 Revised:2025-09-02 Accepted:2025-10-11 Online:2025-10-11
Supported by:
Supported by the National Natural Science Foundation of China (Nos. 32270601, 32070633 and 32570667), the Ministry of Education of the People’s Republic of China (No. Q2024230), the Natural Science Foundation of Chongqing (Nos. CSTB2024NSCQ-MSX0710 and cstc2022ycjh-bgzxm0140), the Fundamental Research Funds for the Central Universities (No. 2024IAIS-QN006) and the Outstanding Young Medical Talents Program of Chongqing (No. YXQN2025071)

摘要/Abstract

摘要：

环状RNA是一类在真核细胞中广泛存在、结构稳定且功能多样的单链RNA分子。除了作为直接调控因子，环状RNA也能通过编码功能性蛋白间接参与多种生理病理进程。目前，环状RNA翻译的分子机制与研究手段、其编码蛋白与重大疾病的关联，以及其作为药用蛋白表达载体的应用前景，已成为生物医学领域的前沿焦点。本文从上述三个方面对可翻译环状RNA的研究现状进行了归纳总结，旨在为环状RNA的前沿研究提供借鉴和参考。

关键词: 环状RNA, 翻译调控, 内部核糖体进入位点, m⁶A, RNA结合蛋白

Abstract:

Circular RNAs (circRNAs) are a class of stable single-stranded RNA molecules with diverse biological functions in eukaryotic cells. Beyond acting as direct regulatory factors, circRNAs can also indirectly participate in various physiological and pathological processes through their encoded functional proteins. The molecular mechanisms and research strategies of circRNA translation, the association between circRNA-encoded proteins and major human diseases, as well as the application of circRNAs as expression vectors for therapeutic proteins, have become cutting-edge focuses in the biomedical field. Focusing on the three above-mentioned aspects in this review, we summarize the current progress of translatable circRNA studies, aiming to provide comprehensive insights and perspectives into the field of circRNA translation.

Key words:

, circRNA, translation, internal ribosomal entry sites, m⁶A, RNA binding protein

邹光福, 周敏, 黄川. 可翻译环状RNA研究进展[J]. 遗传, doi: 10.16288/j.yczz.25-153.

可翻译环状RNA研究进展

Advances in translatable circular RNAs

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