N4-乙酰胞苷修饰在动物生殖发育中的研究进展

doi:10.16288/j.yczz.25-267

遗传 ›› 2026, Vol. 48 ›› Issue (3): 272-286.doi: 10.16288/j.yczz.25-267

N⁴-乙酰胞苷修饰在动物生殖发育中的研究进展

祝新月(), 胡坤隆, 徐雯睆, 轩梦庆, 甘信琪, 杨智元, 王文卓, 刘郑秋, 张梦雅, 周贝贝, 俞文杰, 张运海, 曹祖兵()

安徽农业大学动物科技学院，地方畜禽遗传资源保护与种质创新安徽省重点实验室，合肥 230036

收稿日期:2025-10-13 修回日期:2025-12-17 出版日期:2026-01-15 发布日期:2026-01-15
通讯作者: 曹祖兵，博士，教授，研究方向：动物胚胎工程。E-mail: zubingcao@ahau.edu.cn
作者简介:祝新月，硕士研究生，专业方向：动物遗传育种与繁殖。E-mail: 19154179850@163.com
基金资助:
国家重点研发计划子课题(2023YFD1300502-1);安徽省现代农业产业技术体系岗位专家项目(AHCYJSTX-04);安徽农业大学高层次人才科研启动项目(rc392504)

Progress on N⁴-acetylcytidine in animal reproductive development

Xinyue Zhu(), Kunlong Hu, Wenhuan Xu, Mengqing Xuan, Xinqi Gan, Zhiyuan Yang, Wenzhuo Wang, Zhengqiu Liu, Mengya Zhang, Beibei Zhou, Wenjie Yu, Yunhai Zhang, Zubing Cao()

Key Laboratory of Local Livestock Genetic Resources Conservation and Germplasm Innovation of Anhui Province, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China

Received:2025-10-13 Revised:2025-12-17 Published:2026-01-15 Online:2026-01-15
Supported by:
Sub-project of the National Key Research and Development Program(2023YFD1300502-1);Expert Position Project of the Modern Agricultural Industry Technology System of Anhui Province(AHCYJSTX-04);Startup Foundation for High-level Talents of Anhui Agricultural University(rc392504)

摘要/Abstract

摘要：

N⁴-乙酰胞苷(N⁴-acetylcytidine，ac⁴C)是一类新兴的RNA表观修饰，近年来在表观转录组学研究中被广泛关注。该修饰广泛存在于tRNA、rRNA、mRNA及非编码RNA中，通过精准调控RNA的稳定性与翻译效率，影响下游基因的表达网络，进而对细胞功能产生重要影响。本文综述了ac⁴C修饰的分布特征、生物学功能及复杂调控机制的最新研究进展，详细介绍了其编码器、检测方法以及在动物生殖发育中的作用，旨在为深入探讨ac⁴C修饰在动物繁殖与人类生殖等领域的调控机制提供坚实的理论基础与研究思路。

关键词: N⁴-乙酰胞苷, RNA修饰, 表观遗传, 配子成熟, 胚胎发育

Abstract:

N⁴-acetylcytidine (ac⁴C) is an emerging RNA epigenetic modification that has attracted considerable attention in the field of epitranscriptomics in recent years. This modification is widely present in tRNA, rRNA, mRNA, and various non-coding RNAs. By precisely regulating RNA stability and translational efficiency, ac⁴C modulates the expression network of downstream genes, thereby playing a critical role in cellular function. In this review, we summarize recent advances in the distribution patterns, biological functions, and regulatory mechanisms of ac⁴C, highlight the associated writer enzymes, detection methodologies, and the involvement of ac⁴C in animal reproductive development. We aim to provide a solid theoretical foundation and valuable research insights for future investigations into the regulatory mechanisms of ac⁴C modification in animal and human reproduction.

Key words: ac⁴C, RNA modification, epigenetics, gamete maturation, embryonic development

祝新月, 胡坤隆, 徐雯睆, 轩梦庆, 甘信琪, 杨智元, 王文卓, 刘郑秋, 张梦雅, 周贝贝, 俞文杰, 张运海, 曹祖兵. N⁴-乙酰胞苷修饰在动物生殖发育中的研究进展[J]. 遗传, 2026, 48(3): 272-286.

Xinyue Zhu, Kunlong Hu, Wenhuan Xu, Mengqing Xuan, Xinqi Gan, Zhiyuan Yang, Wenzhuo Wang, Zhengqiu Liu, Mengya Zhang, Beibei Zhou, Wenjie Yu, Yunhai Zhang, Zubing Cao. Progress on N⁴-acetylcytidine in animal reproductive development[J]. Hereditas(Beijing), 2026, 48(3): 272-286.

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N⁴-乙酰胞苷修饰在动物生殖发育中的研究进展

Progress on N⁴-acetylcytidine in animal reproductive development

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