[1] Ishino Y, Shinagawa H, Makino K, Amemura M, Nakata A. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. J Bacteriol , 1987, 169(12): 5429-5433.
[2] Doudna JA, Charpentier E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science , 2014, 346(6213): 1258096.
[3] Hsu PD, Lander ES, Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell , 2014, 157(6): 1262-1278.
[4] Wang HY, Yang H, Shivalila CS, Dawlaty MM, Cheng AW, Zhang F, Jaenisch R. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell , 2013, 153(4): 910-918.
[5] Yang H, Wang HY, Shivalila CS, Cheng AW, Shi LY, Jaenisch R. One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell , 2013, 154(6): 1370-1379.
[6] Zhou XQ, Xin JG, Fan NN, Zou QJ, Huang J, Ouyang Z, Zhao Y, Zhao BT, Liu ZM, Lai SS, Yi XL, Guo L, Esteban MA, Zeng YZ, Yang HQ, Lai LX. Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer. Cell Mol Life Sci , 2015, 72(6): 1175-1184.
[7] Wan HF, Feng CJ, Teng F, Yang SH, Hu BY, Niu YY, Xiang AP, Fang WZ, Ji WZ, Li W, Zhao XY, Zhou Q. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res , 2015, 25(2): 258-261.
[8] Zhao P, Zhang Z, Ke HM, Yue YR, Xue D. Oligonucleotide-based targeted gene editing in C. elegans via the CRISPR/Cas9 system. Cell Res , 2014, 24(2): 247-250.
[9] Hruscha A, Krawitz P, Rechenberg A, Heinrich V, Hecht J, Haass C, Schmid B. Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish. Development , 2013, 140(24): 4982-4987.
[10] Hwang WY, Fu YF, Reyon D, Maeder ML, Tsai SQ, Sander JD, Peterson RT, Yeh JRJ, Joung JK. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol , 2013, 31(3): 227-229.
[11] Shan QW, Wang YP, Li J, Zhang Y, Chen KL, Liang Z, Zhang K, Liu JX, Xi JZJ, Qiu JL, Gao CX. Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol , 2013, 31(8): 686-688.
[12] Konermann S, Brigham MD, Trevino AE, Joung J, Abudayyeh OO, Barcena C, Hsu PD, Habib N, Gootenberg JS, Nishimasu H, Nureki O, Zhang F. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature , 2015, 517(7536): 583-588.
[13] Bikard D, Jiang WY, Samai P, Hochschild A, Zhang F, Marraffini LA. Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res , 2013, 41(15): 7429-7437.
[14] Liu T, Li YJ, Wang XD, Ye Q, Li H, Liang YX, She QX, Peng N. Transcriptional regulator-mediated activation of adaptation genes triggers CRISPR de novo spacer acquisition. Nucleic Acids Res , 2015, 43(2): 1044-1055.
[15] Zhou JW, Xu QB, Yao J, Yu SM, Cao SZ. CRISPR/Cas9 genome editing technique and its application in site-directed genome modification of animals. Hereditas (Beijing) , 2015, 37(10): 1011-1020. 周金伟, 徐绮嫔, 姚婧, 余树民, 曹随忠. CRISPR/Cas9基因组编辑技术及其在动物基因组定点修饰中的应用. 遗传, 2015, 37(10): 1011-1020.
[16] Kraft K, Geuer S, Will AJ, Chan WL, Paliou C, Borschiwer M, Harabula I, Wittler L, Franke M, Ibrahim DM, Kragesteen BK, Spielmann M, Mundlos S, Lupiáñez DG, Andrey G. Deletions, inversions, duplications: engineering of structural variants using CRISPR/Cas in mice. Cell Rep , 2015, 10(5): 833-839, doi:
10.1016/ j.celrep. 2015.01.016.
[17] Stell A, Biserni A, Della Torre S, Rando G, Ramachandran B, Ottobrini L, Lucignani G, Maggi A, Ciana P. Cancer modeling: modern imaging applications in the generation of novel animal model systems to study cancer progression and therapy. Int J Biochem Cell Biol , 2007, 39(7-8): 1288-1296.
[18] van Dy
