N6-甲基腺苷修饰对女性生殖系统功能的影响
收稿日期: 2023-03-23
修回日期: 2023-05-12
网络出版日期: 2023-05-17
基金资助
江苏省重点研发计划项目(BE2022843);国家自然科学基金项目(62273175);国家自然科学基金项目(62003165);国家自然科学基金项目(61973155)
Effects of N6-methyladenosine modification on the function of the female reproductive system
Received date: 2023-03-23
Revised date: 2023-05-12
Online published: 2023-05-17
Supported by
Key R&D Plan Projects in Jiangsu Province(BE2022843);National Natural Science Foundation of China(62273175);National Natural Science Foundation of China(62003165);National Natural Science Foundation of China(61973155)
近年来女性不孕不育率不断攀升，已成为我国提高生育率亟需解决的困境。生殖系统的健康是保证生育能力的前提条件。N 6-甲基腺苷(N6-methyladenosine，m6A)是真核生物中最常见的化学修饰，在细胞生命活动中发挥着极其重要的作用。近来，m6A修饰被证实在女性生殖系统的各种生理和病理过程中起着关键作用，但其调控机制及生物学功能仍不清楚。本文首先介绍了m6A修饰的可逆调节机制及其功能，随后讨论了其在女性生殖功能和生殖系统疾病中的作用，最后对m6A修饰的检测技术和方法及其最新进展进行了归纳总结，以期为后续女性生殖系统发病机制和治疗研究提供参考。
何山, 赵健, 宋晓峰 . N6-甲基腺苷修饰对女性生殖系统功能的影响[J]. 遗传, 2023 , 45(6) : 472 -487 . DOI: 10.16288/j.yczz.23-071
In recent years, the rate of female infertility in China has been increasing, posing an urgent challenge to improve fertility. A healthy reproductive system is essential for successful reproduction, and N6-methyladenosine (m6A) is the most abundant chemical modification in eukaryotes and plays a critical role in cellular processes. Recent studies have shown that m6A modifications also have a keying effect in various physiological and pathological processes in the female reproductive system, although their regulatory mechanisms and biological functions remain unclear. In this review, we first introduce the reversible regulatory mechanisms of m6A and its functions, discuss the role of m6A in female reproductive function and disorders of the reproductive system, and present recent advances in m6A detection technologies and methods. Our review provides new insights into the biological role of m6A and its potential application in the treatment of female reproductive disorders.
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