分枝杆菌T7SS (ESX)分泌系统功能研究进展
收稿日期: 2023-07-10
修回日期: 2023-09-12
网络出版日期: 2023-09-18
基金资助
国家自然科学基金项目(4112000164)
Progress on the function of Mycobacterium T7SS (ESX) secretion system
Received date: 2023-07-10
Revised date: 2023-09-12
Online published: 2023-09-18
Supported by
National Natural Science Foundation of China(4112000164)
蒋智勇, 谢建平 . 分枝杆菌T7SS (ESX)分泌系统功能研究进展[J]. 遗传, 2023 , 45(12) : 1100 -1113 . DOI: 10.16288/j.yczz.23-188
Mycobacterium infection can affect the host’s immune function by secreting extracellular effector proteins. ESX (or type VII) system plays an important role in the secretion of effector proteins. ESX system is the protein export system in mycobacteria and many actinomycetes. However, how ESX system secretes and underlying mechanism of action remain unclear. In this review, we introduce the components, function, classification of ESX system and the process of substrates transfer to the peripheral space via this system, and discuss the roles of ESX system in antibiotics resistance, persistence, host-phage interaction, new drug targets. We hope to provide insights into the discovery of new drugs and vaccine antigens for tuberculosis.
Key words： ESX system; Mycobacterium; membrane complex; antibiotic; virulence factor
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