收稿日期: 2025-07-12
修回日期: 2025-09-02
网络出版日期: 2025-10-11
基金资助
国家自然科学基金项目(32270601);国家自然科学基金项目(32070633);国家自然科学基金项目(32570667);中华人民共和国教育部重大人才项目(Q2024230);重庆市自然科学基金项目(CSTB2025NSCQ-JQX0023);重庆市自然科学基金项目(CSTB2024NSCQ-MSX0710);重庆市自然科学基金项目(cstc2022ycjh-bgzxm0140);中央高校基础研究经费(2024IAIS-QN006);重庆市医学青年拔尖人才项目(YXQN2025071)
Advances in translatable circular RNAs
Received date: 2025-07-12
Revised date: 2025-09-02
Online published: 2025-10-11
Supported by
National Natural Science Foundation of China(32270601);National Natural Science Foundation of China(32070633);National Natural Science Foundation of China(32570667);Ministry of Education of the People’s Republic of China(Q2024230);Natural Science Foundation of Chongqing(CSTB2025NSCQ-JQX0023);Natural Science Foundation of Chongqing(CSTB2024NSCQ-MSX0710);Natural Science Foundation of Chongqing(cstc2022ycjh-bgzxm0140);Fundamental Research Funds for the Central Universities(2024IAIS-QN006);Outstanding Young Medical Talents Program of Chongqing(YXQN2025071)
邹光福, 周敏, 黄川 . 可翻译环状RNA研究进展[J]. 遗传, 2026 , 48(3) : 244 -261 . DOI: 10.16288/j.yczz.25-153
Circular RNAs (circRNAs) are a class of stable single-stranded RNA molecules with diverse biological functions in eukaryotic cells. Beyond acting as direct regulatory factors, circRNAs can also indirectly participate in various physiological and pathological processes through their encoded functional proteins. The molecular mechanisms and research strategies of circRNA translation, the association between circRNA-encoded proteins and major human diseases, as well as the application of circRNAs as expression vectors for therapeutic proteins, have become cutting-edge focuses in the biomedical field. Focusing on the three above-mentioned aspects in this review, we summarize the current progress of translatable circRNA studies, aiming to provide comprehensive insights and perspectives into the field of circRNA translation.
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