N4-乙酰胞苷修饰在动物生殖发育中的研究进展

doi:10.16288/j.yczz.25-267

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Hereditas(Beijing) ›› 2026, Vol. 48 ›› Issue (3): 272-286.doi: 10.16288/j.yczz.25-267

• Review • Previous Articles Next Articles

Progress on N⁴-acetylcytidine in animal reproductive development

Xinyue Zhu(), Kunlong Hu, Wenhuan Xu, Mengqing Xuan, Xinqi Gan, Zhiyuan Yang, Wenzhuo Wang, Zhengqiu Liu, Mengya Zhang, Beibei Zhou, Wenjie Yu, Yunhai Zhang, Zubing Cao()

Key Laboratory of Local Livestock Genetic Resources Conservation and Germplasm Innovation of Anhui Province, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China

Received:2025-10-13 Revised:2025-12-17 Online:2026-01-15 Published:2026-01-15
Contact: Zubing Cao E-mail:19154179850@163.com;zubingcao@ahau.edu.cn
Supported by:
Sub-project of the National Key Research and Development Program(2023YFD1300502-1);Expert Position Project of the Modern Agricultural Industry Technology System of Anhui Province(AHCYJSTX-04);Startup Foundation for High-level Talents of Anhui Agricultural University(rc392504)

Abstract

Abstract:

N⁴-acetylcytidine (ac⁴C) is an emerging RNA epigenetic modification that has attracted considerable attention in the field of epitranscriptomics in recent years. This modification is widely present in tRNA, rRNA, mRNA, and various non-coding RNAs. By precisely regulating RNA stability and translational efficiency, ac⁴C modulates the expression network of downstream genes, thereby playing a critical role in cellular function. In this review, we summarize recent advances in the distribution patterns, biological functions, and regulatory mechanisms of ac⁴C, highlight the associated writer enzymes, detection methodologies, and the involvement of ac⁴C in animal reproductive development. We aim to provide a solid theoretical foundation and valuable research insights for future investigations into the regulatory mechanisms of ac⁴C modification in animal and human reproduction.

Key words: ac⁴C, RNA modification, epigenetics, gamete maturation, embryonic development

Xinyue Zhu, Kunlong Hu, Wenhuan Xu, Mengqing Xuan, Xinqi Gan, Zhiyuan Yang, Wenzhuo Wang, Zhengqiu Liu, Mengya Zhang, Beibei Zhou, Wenjie Yu, Yunhai Zhang, Zubing Cao. Progress on N⁴-acetylcytidine in animal reproductive development[J]. Hereditas(Beijing), 2026, 48(3): 272-286.

Figures/Tables 3

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Progress on N⁴-acetylcytidine in animal reproductive development

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