遗传 ›› 2019, Vol. 41 ›› Issue (10): 893-904.doi: 10.16288/j.yczz.19-065

• 综述 •    下一篇

线粒体代谢介导的表观遗传改变与衰老研究

潘云枫,王演怡,陈静雯,范怡梅()   

  1. 南京大学医学院,南京 210093
  • 收稿日期:2019-04-08 修回日期:2019-06-08 出版日期:2019-10-20 发布日期:2019-06-10
  • 通讯作者: 范怡梅 E-mail:ymfan@nju.edu.cn
  • 作者简介:潘云枫,本科生,专业方向:临床医学。E-mail: 161232029@smail.nju.edu.cn;|王演怡,本科生,专业方向:口腔医学。E-mail: 161232043@smail.nju.edu.cn; 潘云枫和王演怡并列第一作者。
  • 基金资助:
    国家自然科学基金面上项目资助编号:(81771504)

Mitochondrial metabolism’s effect on epigenetic change and aging

Pan Yunfeng,Wang Yanyi,Chen Jingwen,Fan Yimei()   

  1. Medical School, Nanjing University, Nanjing 210093, China
  • Received:2019-04-08 Revised:2019-06-08 Online:2019-10-20 Published:2019-06-10
  • Contact: Fan Yimei E-mail:ymfan@nju.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China No.(81771504)

摘要:

线粒体是细胞物质代谢与能量代谢的中心,在多种生理和病理过程中扮演着重要角色。表观遗传修饰是一种独立于DNA序列并在建立与维持特定基因表达谱中发挥主要作用的遗传调控模式。近年来的研究表明,线粒体能量代谢通过中间产物,介导线粒体-核信号的传递,调节染色质的表观修饰状态,进而影响基因表达。线粒体代谢紊乱可以诱导表观遗传重编程,进而启动衰老表型及退行性疾病的发生。本文综述了线粒体代谢与染色质表观遗传修饰关系的研究进展,探讨了线粒体应激在染色质重组中发挥的作用,展望了其在认知功能障碍等衰老相关性疾病研究中的前景。

关键词: 线粒体代谢, DNA甲基化, 组蛋白修饰, 衰老, UPR mt

Abstract:

Mitochondrion is the metabolic center and powerhouse of cells producing cellular energy which plays an important role in various physiological and pathophysiological processes. Recent research demonstrates that mitochondrial energy metabolism mediates the transmission of mitochondrial-nuclear signals through intermediate products which regulates epigenetic presentation of the chromatin and thereby affects gene expression. Epigenetic modification, a genetic regulatory model, is independent of DNA sequence and plays a major role in establishing and maintaining a specific gene’s expression profile. Disorders of mitochondrial metabolism can induce epigenetic reprogramming which in turn initiates aging phenotypes and degenerative diseases. This review introduces recent research progress on the relationship between mitochondrial metabolism and chromatin-related epigenetic modification, discusses the role of mitochondrial stress in chromatin recombination, and suggests future research directions and their application in the study of age-related diseases such as cognitive dysfunction.

Key words: mitochondrial metabolism, DNA methylation, histone modifications, aging, UPR mt