N6-腺苷甲基化修饰及其对LINE-1的调控机制

doi:10.16288/j.yczz.23-248

遗传 ›› 2024, Vol. 46 ›› Issue (3): 209-218.doi: 10.16288/j.yczz.23-248

N⁶-腺苷甲基化修饰及其对LINE-1的调控机制

张傲(), 岑山(), 李晓宇()

中国医学科学院&北京协和医学院，医药生物技术研究所免疫生物学室，北京 100050

收稿日期:2023-11-10 修回日期:2023-12-28 出版日期:2024-03-20 发布日期:2024-01-19
通讯作者: 岑山，博士，研究员，研究方向：病毒学。E-mail: shancen@hotmail.com;
李晓宇，博士，研究员，研究方向：病毒学。E-mail: xiaoyulik@hotmail.com
作者简介:张傲，硕士研究生，专业方向：LINE-1与肿瘤维持机制的研究。E-mail: za1632649341@163.com
基金资助:
国家自然科学基金面上项目(31870164)

N⁶-adenosine methylation and the regulatory mechanism on LINE-1

Ao Zhang(), Shan Cen(), Xiaoyu Li()

Department of Immunology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Received:2023-11-10 Revised:2023-12-28 Published:2024-03-20 Online:2024-01-19
Supported by:
National Natural Science Foundation of China(31870164)

摘要/Abstract

摘要：

长散布元件-1 (long interspersed elements-1，LINE-1)是现今在人类基因组中唯一具有自主转座能力的转座子，其转座会引起细胞基因组结构和功能的改变，是导致多种严重疾病的重要因素。在转座过程中，LINE-1 mRNA是转座中间体的核心，宿主细胞对其进行相关修饰直接影响转座。N⁶-腺苷甲基化修饰(m⁶A)是真核细胞RNA上最丰富且动态可逆的表观遗传修饰。目前发现m⁶A修饰也存在于LINE-1 mRNA上，参与LINE-1整个生命周期的调控，影响其转座和基因组中LINE-1相邻基因的表达，进而影响基因组稳定性、细胞自我更新与分化潜能，在人类发育和疾病中具有重要作用。本文介绍了LINE-1 m⁶A修饰的位置、功能以及相关机制，并总结了LINE-1的m⁶A修饰对其转座调控的研究进展，以期为相关疾病发生发展的机制研究和治疗提供新的思路。

关键词: m⁶A修饰, 逆转录转座子, LINE-1, 基因组, 基因组稳定性

Abstract:

Long interspersed elements-1(LINE-1) is the only autonomous transposon in human genome，and its retrotransposition results in change of cellular genome structure and function, leading occurrence of various severe diseases. As a central key intermediated component during life cycle of LINE-1 retrotransposition, the host modification of LINE-1 mRNA affects the LINE-1 transposition directly. N⁶-adenosine methylation(m⁶A), the most abundant epigenetic modification on eukaryotic RNA, is dynamically reversible. m⁶A modification is also found on LINE-1 mRNA, and it participants regulation of the whole LINE-1 replication cycle, with affecting LINE-1 retrotransposition as well as its adjacent genes expression, followed by influencing genomic stability, cellular self-renewal, and differentiation potential, which plays important roles in human development and diseases. In this review, we summarize the research progress in LINE-1 m⁶A modification, including its modification positions, patterns and related mechanisms, hoping to provide a new sight on the mechanism research and treatment of related diseases.

Key words: m⁶A modification, retrotransposon, LINE-1, genome, genome stability

张傲, 岑山, 李晓宇. N⁶-腺苷甲基化修饰及其对LINE-1的调控机制[J]. 遗传, 2024, 46(3): 209-218.

Ao Zhang, Shan Cen, Xiaoyu Li. N⁶-adenosine methylation and the regulatory mechanism on LINE-1[J]. Hereditas(Beijing), 2024, 46(3): 209-218.

图/表 2

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N⁶-腺苷甲基化修饰及其对LINE-1的调控机制

N⁶-adenosine methylation and the regulatory mechanism on LINE-1

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