circRNA及其调控动物骨骼肌发育研究进展

doi:10.16288/j.yczz.20-207

遗传 ›› 2020, Vol. 42 ›› Issue (12): 1178-1191.doi: 10.16288/j.yczz.20-207

circRNA及其调控动物骨骼肌发育研究进展

郑婷¹, 甘麦邻¹, 沈林園¹, 牛丽莉¹, 郭宗义², 王金勇², 张顺华¹(), 朱砺¹()

^1. 四川农业大学动物科技学院,成都 611130
^2. 重庆市畜牧科学院,荣昌 402460

收稿日期:2020-07-06 修回日期:2020-10-13 出版日期:2020-12-17 发布日期:2020-12-01
通讯作者: 张顺华,朱砺 E-mail:363445986@qq.com;zhuli7508@163.com
作者简介:郑婷,在读硕士研究生,专业方向：动物遗传育种。E-mail: 741377392@qq.com
基金资助:
国家自然科学基金项目编号(31972524);国家现代农业产业技术体系四川生猪创新团队项目编号(SCSZTD-3-008);四川省科技支撑计划项目资助编号(2016NYZ0050)

circRNA on animal skeletal muscle development regulation

Ting Zheng¹, Mailin Gan¹, Linyuan Shen¹, Lili Niu¹, Zongyi Guo², Jinyong Wang², Shunhua Zhang¹(), Li Zhu¹()

^1. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
^2. ChongQing Academy of Animal Sciences, Rongchang 402460, China

Received:2020-07-06 Revised:2020-10-13 Online:2020-12-17 Published:2020-12-01
Contact: Zhang Shunhua,Zhu Li E-mail:363445986@qq.com;zhuli7508@163.com
Supported by:
Supported by the National Natural Science Foundation of China No(31972524);Sichuan Pig Innovation Team Project of National Modern Agricultural Industrial Technology System(SCSZTD-3-008);the Science and Technology Program of Sichuan Province No(2016NYZ0050)

摘要/Abstract

摘要：

环状RNA (circular RNA, circRNA)是一类反向剪接形成的闭合环状RNA分子,广泛存在于生物体内,近年来成为非编码RNA中的研究热点。骨骼肌在生物体中起到协调运动的作用,是维持体内正常代谢和内分泌的器官之一。随着测序技术和生物信息学分析技术的发展,circRNA在动物骨骼肌发育中的功能和调控机制逐渐被揭示。本文就当前circRNA的分子调控机制类型、circRNA经典研究思路及功能研究方法以及circRNA参与骨骼肌正常发育与骨骼肌疾病发生调控的研究进展进行了综述,以期为进一步深入研究circRNA参与骨骼肌生长发育调控的遗传机制以及circRNA相关研究方法提供参考。

关键词: 环状RNA, 骨骼肌发育, 骨骼肌疾病, RNA测序

Abstract:

Circular RNA (circRNA) is a type of closed circular RNA molecules formed by reverse splicing, which exists widely in organisms and has become a research hotspot in non-coding RNAs in recent years. Skeletal muscle plays the role of coordinating movement and maintaining normal metabolism and endocrine in organisms. With the development of sequencing and bioinformatics analysis technology, the functions and regulation mechanisms of circRNAs in skeletal muscle development have been gradually revealed. In this review, we summarize the types of molecular regulatory mechanisms, the classical research ideas and the functional research methods of circRNAs, and the research progress of circRNAs involved in normal development of skeletal muscle and regulation of skeletal muscle disease, in order to provide a reference to further study of the genetic mechanisms of circRNAs in the regulation of skeletal muscle development.

Key words: circRNA, skeletal muscle development, skeletal muscle diseases, RNA-seq

郑婷, 甘麦邻, 沈林園, 牛丽莉, 郭宗义, 王金勇, 张顺华, 朱砺. circRNA及其调控动物骨骼肌发育研究进展[J]. 遗传, 2020, 42(12): 1178-1191.

Ting Zheng, Mailin Gan, Linyuan Shen, Lili Niu, Zongyi Guo, Jinyong Wang, Shunhua Zhang, Li Zhu. circRNA on animal skeletal muscle development regulation[J]. Hereditas(Beijing), 2020, 42(12): 1178-1191.

图/表 4

图1

图2

Table 1

circRNAs involved in the regulation of skeletal muscle development in different animals"

circRNA		物种	可能作用机制	生物学功能
circZNF609	人(Homo sapiens)	编码蛋白质	促进成肌细胞增殖	[28]
circZNF609	小鼠(Mus musculus)	编码蛋白质	促进成肌细胞增殖	[28]
circLMO7	牛(Bos taurus)	吸附miR-378-3p,靶基因为HDAC4	促进成肌细胞增殖, 抑制分化和凋亡	[70]
circRBFOX2	鸡(Gallus gallus)	吸附miR-206,靶基因为CCND2	促进成肌细胞增殖	[74]
circFUT10	牛(Bos taurus)	吸附miR-133a,靶基因为SRF	抑制成肌细胞增殖, 促进成肌细胞分化	[75]
circSVIL	鸡(Gallus gallus)	吸附miR-203,靶基因为c-Jun、MEF2C	促进成肌细胞增殖、分化	[76]
circFGFR4	牛(Bos taurus)	吸附miR-107,靶基因为Wnt3a	促进成肌细胞分化,诱导凋亡	[49]
circZfp609	小鼠(Mus musculus)	吸附miR-194-5p,靶基因为BCLAF1	抑制成肌细胞分化	[77]
circHIPK3	鸡(Gallus gallus)	吸附miR-30a-3p,靶基因为MEF2C	促进成肌细胞增殖、分化	[50]
circFoxO3	小鼠(Mus musculus)	吸附miR-138-5p	抑制成肌细胞分化	[78]
circSNX29	牛(Bos taurus)	吸附miR-744,靶基因为Wnt5a	抑制成肌细胞增殖、促进成肌细胞分化	[79]
circTMTC1	鸡(Gallus gallus)	吸附miR-128-3p,靶基因为MSTN	抑制骨骼肌卫星细胞增殖、分化	[80]
circCDR1as	山羊(Capra hircus)	吸附miR-7,靶基因为IGF1R	促进骨骼肌卫星细胞成肌分化	[81]
circTTN	牛(Bos taurus)	吸附miR-432,靶基因为IGF2	促进成肌细胞增殖、分化	[82]
circHIPK3	小鼠(Mus musculus)	吸附miR-124-5p和miR-379-5p	促进成肌细胞分化	[83]
circTUT7	猪(Sus scrofa)	吸附miR-30a-3p,靶基因为HMG20B	促进胚胎肌生成相关基因转录	[73]
circINSR	牛(Bos taurus)	吸附miR-34a,靶基因为Bcl-2、CyclinE2	促进成肌细胞增殖、抑制凋亡	[51]
circHUWE1	牛(Bos taurus)	吸附miR-29b,靶基因为AKT3	促进成肌细胞增殖、抑制凋亡及分化	[84]
circSamd4	小鼠(Mus musculus)	与PUR蛋白结合	促进成肌细胞分化	[85]

Table 1

表2

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circRNA	物种	组织/细胞	疾病类型	表达模式	参考文献
circQKI	人(Homo sapiens)	原代肌细胞	DMD	下调	[28]
circBNC2	人(Homo sapiens)	原代肌细胞	DMD	下调	[28]
circZFP609	人(Homo sapiens)	原代肌细胞	DMD	上调	[28]
circCDYL	人(Homo sapiens)	骨骼肌组织	DM1	上调	[103]
circHIPK3	人(Homo sapiens)	骨骼肌组织	DM1	上调	[103]
circRTN4-03	人(Homo sapiens)	骨骼肌/肌源性细胞	DM1	上调	[103]
circZFP609	人(Homo sapiens)	骨骼肌/肌源性细胞	DM1	上调	[103]
circCAMSAP1	小鼠(Mus musculus)	骨骼肌组织	DM1	上调	[102]
circHIPK3	小鼠(Mus musculus)	骨骼肌组织	DM1	上调	[102]
circNFATC3	小鼠(Mus musculus)	骨骼肌组织	DM1	上调	[102]
circZfp609	小鼠(Mus musculus)	骨骼肌组织	DM1	上调	[102]
circBBS9	小鼠(Mus musculus)	骨骼肌组织	Sarcopenia	下调	[104]
circCAMK2D	人(Homo sapiens)	心肌组织	HCM/DCM	下调	[94]
circTTN	人(Homo sapiens)	心肌组织	DCM	下调	[94]

circRNA及其调控动物骨骼肌发育研究进展

circRNA on animal skeletal muscle development regulation

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