精子尾部发育相关蛋白研究进展

doi:10.16288/j.yczz.19-309

遗传 ›› 2020, Vol. 42 ›› Issue (6): 524-535.doi: 10.16288/j.yczz.19-309

精子尾部发育相关蛋白研究进展

钟亚楠, 牛长敏, 夏蒙蒙, 郑英

扬州大学医学院组织学与胚胎学教研室,扬州 225001

收稿日期:2019-12-25 修回日期:2020-04-02 出版日期:2020-06-20 发布日期:2020-05-07
作者简介:钟亚楠,在读硕士研究生,专业方向：生殖医学。E-mail: 415833840@qq.com
基金资助:
国家自然科学基金项目编号(81871205);江苏省自然科学基金项目资助编号(BK20131230)

Research progress of proteins related to sperm tail development

Yanan Zhong, Changmin Niu, Mengmeng Xia, Ying Zheng

Department of Histology and Embryology, School of Medicine, Yangzhou University, Yangzhou 225001, China

Received:2019-12-25 Revised:2020-04-02 Published:2020-06-20 Online:2020-05-07
Supported by:
Supported by the National Natural Science Foundation of China No(81871205);the Natural Science Foundation of Jiangsu Province No(BK20131230)

摘要/Abstract

摘要：

精子尾部结构与其运动功能密切相关。精子的运动能力直接决定了精子能否正常运输到输卵管与卵子受精。精子尾部的形成和发育是一个极其复杂的过程,由多种蛋白质精细调控。研究发现,多种精子尾部发育相关蛋白的缺陷可导致少、弱、畸形精子症。本文根据精子尾部的超微结构顺序,对近年来精子尾部发育相关蛋白的研究进展进行综述,以期为男性不育症的遗传学诊断和治疗提供理论基础和实践的可能。

关键词: 精子尾部, 发育, 蛋白, 研究进展

Abstract:

The structure of sperm tail is closely related to its motor function, which directly determines whether the sperm can be normally transported to fallopian tube and fertilize the ovum. The formation and development of sperm tail is a very complex process, which is finely regulated by various kinds of proteins. Research finds that defects of various sperm tail development related proteins can lead to oligospermia, asthenozoospermia and teratospermia. Based on the ultrastructure of sperm tail, we summarize the recent research progress of the proteins related to sperm tail development, thereby providing the theoretical basis and practical possibility for the diagnosis and treatment of male infertility.

Key words: sperm tail, development, protein, research progress

钟亚楠, 牛长敏, 夏蒙蒙, 郑英. 精子尾部发育相关蛋白研究进展[J]. 遗传, 2020, 42(6): 524-535.

Yanan Zhong, Changmin Niu, Mengmeng Xia, Ying Zheng. Research progress of proteins related to sperm tail development[J]. Hereditas(Beijing), 2020, 42(6): 524-535.

图/表 2

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精子尾部结构	发育相关蛋白
植入窝和基底板	SUN5和OAZ3
小头和节柱	SPATA6
中心体	SPATC1L、CEP135、CFAP43和CFAP44
Manchette	STK33、KIF3A、LRGUK1、SEPT12和MEIG1
轴丝	CFAP69、SPEF2、ARMC2、TCTE1、RSPH6A、DNAH1、DNAH2、C11orf70和PIH1D3
外周致密纤维	ODF1、ODF2、ODF3、Tssk4和MNS1
线粒体鞘	KLC3、MFN2和CFAP251
纤维鞘	FSIP2、AKAP4、AKAP3、ROPN1、ROPN1L、FS39、Als2cr12、Mtsga10、ENO4和CFAP157

精子尾部发育相关蛋白研究进展

Research progress of proteins related to sperm tail development

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参考文献 57

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