小开放阅读框编码微肽的研究进展

doi:10.16288/j.yczz.21-167

遗传 ›› 2021, Vol. 43 ›› Issue (8): 737-746.doi: 10.16288/j.yczz.21-167

小开放阅读框编码微肽的研究进展

陈相颖(), 李梦玮, 王颖, 陈权, 徐寒梅()

中国药科大学江苏省合成多肽药物发现与评价工程中心,南京 211198

收稿日期:2021-05-08 修回日期:2021-07-06 出版日期:2021-08-20 发布日期:2021-07-23
通讯作者: 徐寒梅 E-mail:cxy000111@qq.com;13913925346@126.com
作者简介:陈相颖,在读硕士研究生,专业方向：微生物与生化药学。E-mail: cxy000111@qq.com
基金资助:
中国药科大学天然药物活性组分与药效国家重点实验编号(SKLNMZZCX201821);中国药科大学天然药物活性组分与药效国家重点实验编号(SKLNMZZ202028);国家科技重大新药开发项目编号(2019ZX09301124);国家科技重大新药开发项目编号(2019ZX09201001);国家科技重大新药开发项目编号(2019ZX09301-110);中国博士后科学基金资助项目资助编号(2017M621884);中国博士后科学基金资助项目资助编号(2020M681787)

Progress on sORF-encoded micropeptides

Xiangying Chen(), Mengwei Li, Ying Wang, Quan Chen, Hanmei Xu()

Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation of Jiangsu Province, China Pharmaceutical University, Nanjing 211198, China

Received:2021-05-08 Revised:2021-07-06 Online:2021-08-20 Published:2021-07-23
Contact: Xu Hanmei E-mail:cxy000111@qq.com;13913925346@126.com
Supported by:
Supported by the Project Program of State Key Laboratory of Natural Medicines Nos(SKLNMZZCX201821);Supported by the Project Program of State Key Laboratory of Natural Medicines Nos(SKLNMZZ202028);the National Science and Technology Major Projects of New Drugs Nos(2019ZX09301124);the National Science and Technology Major Projects of New Drugs Nos(2019ZX09201001);the National Science and Technology Major Projects of New Drugs Nos(2019ZX09301-110);China Postdoctoral Science Foundation Nos(2017M621884);China Postdoctoral Science Foundation Nos(2020M681787)

摘要/Abstract

摘要：

已有的研究表明,生命体中存在着大量的非编码RNA (non-coding RNA, ncRNA),先前被错误注释为ncRNA的分子序列中实际上包含小的开放阅读框(short open reading frame, sORF),部分sORF可转录并翻译成进化保守的微肽(micropeptide),这些sORF由于序列较短和研究技术手段的限制而被忽略。迄今为止,已在生命体中发现一些sORF编码的功能各异的微肽,它们对生命活动的调控起着重要作用。本文对近年来发现的功能性微肽进行综述,介绍了本课题组发现新型微肽MIAC (micropeptide inhibiting actin cytoskeleton)的过程,同时总结了研究潜在微肽的相关技术,以期为研究人员利用相关技术发现新微肽提供借鉴和参考。

关键词: 非编码RNA, 小开放阅读框, 微肽

Abstract:

Existing research has shown that there are a large amount of non-coding RNAs (ncRNAs) in organisms. Short open reading frames (sORFs) abundantly exist in molecular sequences inaccurately annotated as ncRNAs. Several sORFs can be transcribed and translated into evolutionarily conserved micropeptides, which were ignored in previous studies due to short sequence lengths and the limitations of research techniques. To date, sORF-encoded micropeptides with various functions have been found to play important roles in regulating vital biological activities. This article reviews the functional micropeptides which have been found in recent years, introduces the new micropeptide designated as MIAC that we have discovered and describes the related technologies for mining potential micropeptides, thereby providing insights and references for new micropeptide discovery for researchers.

Key words: non-coding RNA, small open reading frames, micropeptides

陈相颖, 李梦玮, 王颖, 陈权, 徐寒梅. 小开放阅读框编码微肽的研究进展[J]. 遗传, 2021, 43(8): 737-746.

Xiangying Chen, Mengwei Li, Ying Wang, Quan Chen, Hanmei Xu. Progress on sORF-encoded micropeptides[J]. Hereditas(Beijing), 2021, 43(8): 737-746.

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基因	微肽	长度(氨基酸)	作用	啊啊啊啊
鼠AK009351、人LINC00948	MLN	46	抑制SERCA,调节钙离子转运	[6]
1110017F19Rik/SMIM6	ELN	56	抑制SERCA,调节钙离子转运	[5]
1810037I17Rik	ALN	65	抑制SERCA,调节钙离子转运	[5]
鼠NONMMUG026737、人LOC100507537	DWORF	34	激活SERCA,调节钙离子转运	[8]
pncr003:2L	Scl	28/29	调节钙离子转运,影响肌肉收缩	[7]
鼠1500011K16Rik、人LINC00116	MOXI	56	增强脂肪酸β-氧化作用	[10]
LINC00116	Mtln	56	增强呼吸效率	[11]
12S rRNA	MOTS-c	16	调节胰岛素敏感性	[9]
LOC101929726	Minion	84	促进成肌细胞融合和肌肉发育	[12]
LOC101929726	Myomixer	84	促进成肌细胞融合和肌肉发育	[13]
LOC100506013	Toddler	54	激活APJ/Apelin受体促进胚胎发育	[14]
polished rice(pri)	Pri	11/32	促进胚胎发育中的表皮形成	[15]
Tarsal-less(tal)	Tal	11	控制基因表达和组织折叠	[16]
LINC00961	SPAR	90	抑制mTORC1和肌肉再生	[17]
hemotion	Hemotion	88	促进吞噬细胞吞噬作用	[18]
PIGBOS	PIGBOS	54	调节内质网应激反应	[19]
SMIM22	CASIMO1	83	促进乳腺癌	[20]
HOXB-AS3	HOXB-AS3	53	抑制结肠癌	[21]
LINC00998	SMIM30	59	促进肝癌	[22]
LINC00278	YY1BM	21	抑制食管鳞状细胞癌	[23]
AC025154.2	MIAC	51	抑制头颈鳞状细胞癌	[24]
LINC01420	NoBody	68	促进无义介导的mRNA衰变	[38]
MIR155HG	miPEP155(P155)	17	调节抗原呈递细胞的抗原转运和呈递	[45]

小开放阅读框编码微肽的研究进展

Progress on sORF-encoded micropeptides

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