SMC蛋白的结构和功能

遗传 ›› 2001, Vol. 23 ›› Issue (2): 173-276.

SMC蛋白的结构和功能

彭莉;张飞雄 PENG Li;ZHANG Fei-xiong

首都师范大学生物系，北京 100037 Department of Biology,Capital Normal University,Beijing 100037，China

收稿日期:1900-01-01 出版日期:2001-04-10 发布日期:2001-04-10

The Structure and Function of SMC Proteins

Received:1900-01-01 Online:2001-04-10 Published:2001-04-10

摘要/Abstract

摘要： 近年来新发现的一类蛋白――染色体结构维持蛋白(SMC蛋白，structural maintenance of chromosome proteins)与染色体结构细胞周期性的动态变化紧密相关，它们参与有丝分裂染色体的集缩和分离、性染色体的剂量补偿效应、姐妹染色单体的内聚作用(cohesion)、遗传重组和DNA修复等过程。本文从生化特性和生物学功能两方面叙述了对SMC蛋白的研究。
Abstract：The newly discovered proteins, SMC (structural maintenance of chromosome) proteins, are associated with chromosome dynamics change in the cell cycle. They are involved in chromosome condensation, sister-chromatid cohesion, sex-chromosome dosage compensation, genetic recombination and DNA repair,etc. The current understanding of the biochemical properties and biological functions of SMC proteins is summarized in this paper.

关键词: 集缩蛋白, 染色体结构维持蛋白, structural maintenance of chromosome proteins, 内聚蛋白 Keywords, condensins

彭莉，张飞雄. SMC蛋白的结构和功能[J]. 遗传, 2001, 23(2): 173-276.

PENG Li, ZHANG Fei-xiong. The Structure and Function of SMC Proteins[J]. HEREDITAS, 2001, 23(2): 173-276.