精子功能相关的蛋白质调控受精过程的研究进展

doi:10.3724/SP.J.1005.2014.0747

遗传 ›› 2014, Vol. 36 ›› Issue (8): 747-755.doi: 10.3724/SP.J.1005.2014.0747

精子功能相关的蛋白质调控受精过程的研究进展

陈志林¹, 冯美莹¹, 陈预明¹, 卫恒习¹, 李莉¹, 吴同山², 张守全¹

1. 华南农业大学动物科学学院,国家生猪种业工程技术研究中心,广州 510642;
2. 东莞市畜牧科学研究所,东莞 523086

收稿日期:2014-03-22 出版日期:2014-08-20 发布日期:2013-07-19
通讯作者: 张守全,教授,博士生导师,研究方向：动物遗传与繁育。E-mail:sqzhang@scau.edu.cn
作者简介:陈志林,在读硕士研究生,专业方向：动物遗传与繁育。Tel:020-85285897;E-mail:qq505878698@sina.com
基金资助:
国家科技支撑计划项目(编号：2011BAD19B03),国家重点基础研究发展计划(973计划)项目(编号：2011CB944202; 2009CB941601; 2010CB945001)和东莞市科技计划项目(编号：2012108102049)资助

The progress of sperm functional proteins regulating the process of fertilization

Zhilin Chen¹, Meiying Feng¹, Yuming Chen¹, Hengxi Wei¹, Li Li¹, Tongshan Wu², Shouquan Zhang¹

1. National Engineering Research Center For Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China;
2. Dongguan Institute of Animal Science, Dongguan 523086, China

Received:2014-03-22 Online:2014-08-20 Published:2013-07-19

摘要/Abstract

摘要： 哺乳动物的受精过程涉及到精子一系列的功能活动,如精子在雌性生殖道的运行、精子的超活化与获能、顶体反应以及精卵融合等。在精子经历的这一系列过程中,精子功能相关的蛋白质发挥着不可或缺的作用,这些蛋白分子的正常与否与雄性个体的繁殖力高低密切相关,因此精子功能相关的蛋白质能够作为评定哺乳动物精液受精能力的生物标记。文章主要对哺乳动物精子功能相关的蛋白质进行了综述,以阐述相关蛋白分子对精子运动活力、精子获能、顶体反应、透明带穿入和精卵融合等方面的重要作用以及这些蛋白分子在家畜遗传改良上的潜在应用。

关键词: 受精, 精子, 蛋白质, 生物标记, 繁殖力

Abstract: The process of mammalian fertilization involves a series of sperm functional activities, including the sperm transportation, hyperactivation and capacitation, acrosome reaction and sperm-egg fusion, etc. The semen proteins play indispensable roles in these processes, and they are closely associated with the fecundity of males. So these proteins can be biomarkers to evaluate the fertilization capacity of mammalian semen. In this review, we mainly introduce some semen proteins relevant to spermatozoa functions and illustrate their important regulatory roles on the fertilization processes, involving spermatozoa motility, capacitation, acrosome reaction, penetrating the zona pellucida and sperm-egg fusion, etc. Moreover, their potential applications in the evaluation of heredity in livestock are also summarized.

Key words: fertilization, spermatozoa, protein, biomarkers, fecundity

陈志林, 冯美莹, 陈预明, 卫恒习, 李莉, 吴同山, 张守全. 精子功能相关的蛋白质调控受精过程的研究进展[J]. 遗传, 2014, 36(8): 747-755.

Zhilin Chen, Meiying Feng, Yuming Chen, Hengxi Wei, Li Li, Tongshan Wu, Shouquan Zhang. The progress of sperm functional proteins regulating the process of fertilization[J]. HEREDITAS(Beijing), 2014, 36(8): 747-755.

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精子功能相关的蛋白质调控受精过程的研究进展

The progress of sperm functional proteins regulating the process of fertilization

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