生殖细胞及早期胚胎基因组印记的表观调控

doi:10.16288/j.yczz.15-194

遗传 ›› 2016, Vol. 38 ›› Issue (2): 103-108.doi: 10.16288/j.yczz.15-194

生殖细胞及早期胚胎基因组印记的表观调控

朱屹然,张美玲,翟志超,赵云蛟,马馨

吉林农业大学动物科学技术学院,长春 130118

收稿日期:2015-05-06 修回日期:2015-07-24 出版日期:2016-02-20 发布日期:2015-11-04
通讯作者: 马馨,博士,副教授,研究方向：动物克隆与转基因动物。E-mail: maxin3202@163.com
作者简介:朱屹然,硕士研究生,专业方向：动物克隆与转基因动物。E-mail: zyr901027@163.com
基金资助:
国家自然科学基金青年基金项目(编号：31302047)资助[Supported by the National Natural Science Foundation of China (No; 31302047)]

Epigenetic regulation of genomic imprinting in germline cells and preimplantation embryos

Yiran Zhu, Meiling Zhang, Zhichao Zhai, Yunjiao Zhao, Xin Ma

College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China

Received:2015-05-06 Revised:2015-07-24 Online:2016-02-20 Published:2015-11-04

摘要/Abstract

摘要： 基因组印记是一种区别父母等位基因的表观遗传过程,可导致父源和母源基因特异性表达。印记是在配子发生过程中全基因组表观重编程时获得的,且在早期胚胎发育过程中得以维持。因此,在全基因组重编程过程中,对印记的识别和维持十分重要。本文概述了原始生殖细胞的印记清除、双亲原始生殖细胞的印记获得以及早期胚胎发育过程中印记维持的相关过程,并对在印记区域内保护印记基因免受全基因组DNA去甲基化的表观遗传因子的相关作用机制进行了讨论。

关键词: 基因组印记, DNA甲基化, 早期胚胎发育

Abstract: Genomic imprinting is an epigenetic process that distinguishes parental alleles and results in specific expression of paternal and maternal genes. Imprints are acquired in the process of gametogenesis when genome-wide epigenetic reprogramming occurs and are maintained during early embryonic development. Therefore, the recognition and maintenance of imprints are very important in genome-wide reprogramming. In this review, we summarize the progresses of imprints removal in primordial germ cells (PGCs), imprints acquisition in parental PGCs, and imprints maintenance during early embryonic development. We also discuss the functional mechanisms of epigenetic factors which protect imprinted genes from whole genome DNA methylation.

Key words: genomic imprinting, DNA methylation, preimplantation embryos

朱屹然,张美玲,翟志超,赵云蛟,马馨. 生殖细胞及早期胚胎基因组印记的表观调控[J]. 遗传, 2016, 38(2): 103-108.

Yiran Zhu, Meiling Zhang, Zhichao Zhai, Yunjiao Zhao, Xin Ma. Epigenetic regulation of genomic imprinting in germline cells and preimplantation embryos[J]. HEREDITAS(Beijing), 2016, 38(2): 103-108.

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生殖细胞及早期胚胎基因组印记的表观调控

Epigenetic regulation of genomic imprinting in germline cells and preimplantation embryos

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