遗传 ›› 2020, Vol. 42 ›› Issue (12): 1178-1191.doi: 10.16288/j.yczz.20-207

• 综述 • 上一篇    下一篇

circRNA及其调控动物骨骼肌发育研究进展

郑婷1, 甘麦邻1, 沈林園1, 牛丽莉1, 郭宗义2, 王金勇2, 张顺华1(), 朱砺1()   

  1. 1. 四川农业大学动物科技学院,成都 611130
    2. 重庆市畜牧科学院,荣昌 402460
  • 收稿日期:2020-07-06 修回日期:2020-10-13 出版日期:2020-12-17 发布日期:2020-12-01
  • 通讯作者: 张顺华,朱砺 E-mail:363445986@qq.com;zhuli7508@163.com
  • 作者简介:郑婷,在读硕士研究生,专业方向:动物遗传育种。E-mail: 741377392@qq.com
  • 基金资助:
    国家自然科学基金项目编号(31972524);国家现代农业产业技术体系四川生猪创新团队项目编号(SCSZTD-3-008);四川省科技支撑计划项目资助编号(2016NYZ0050)

circRNA on animal skeletal muscle development regulation

Ting Zheng1, Mailin Gan1, Linyuan Shen1, Lili Niu1, Zongyi Guo2, Jinyong Wang2, Shunhua Zhang1(), Li Zhu1()   

  1. 1. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
    2. ChongQing Academy of Animal Sciences, Rongchang 402460, China
  • Received:2020-07-06 Revised:2020-10-13 Online:2020-12-17 Published:2020-12-01
  • Contact: Zhang Shunhua,Zhu Li E-mail:363445986@qq.com;zhuli7508@163.com
  • Supported by:
    Supported by the National Natural Science Foundation of China No(31972524);Sichuan Pig Innovation Team Project of National Modern Agricultural Industrial Technology System(SCSZTD-3-008);the Science and Technology Program of Sichuan Province No(2016NYZ0050)

摘要:

环状RNA (circular RNA, circRNA)是一类反向剪接形成的闭合环状RNA分子,广泛存在于生物体内,近年来成为非编码RNA中的研究热点。骨骼肌在生物体中起到协调运动的作用,是维持体内正常代谢和内分泌的器官之一。随着测序技术和生物信息学分析技术的发展,circRNA在动物骨骼肌发育中的功能和调控机制逐渐被揭示。本文就当前circRNA的分子调控机制类型、circRNA经典研究思路及功能研究方法以及circRNA参与骨骼肌正常发育与骨骼肌疾病发生调控的研究进展进行了综述,以期为进一步深入研究circRNA参与骨骼肌生长发育调控的遗传机制以及circRNA相关研究方法提供参考。

关键词: 环状RNA, 骨骼肌发育, 骨骼肌疾病, RNA测序

Abstract:

Circular RNA (circRNA) is a type of closed circular RNA molecules formed by reverse splicing, which exists widely in organisms and has become a research hotspot in non-coding RNAs in recent years. Skeletal muscle plays the role of coordinating movement and maintaining normal metabolism and endocrine in organisms. With the development of sequencing and bioinformatics analysis technology, the functions and regulation mechanisms of circRNAs in skeletal muscle development have been gradually revealed. In this review, we summarize the types of molecular regulatory mechanisms, the classical research ideas and the functional research methods of circRNAs, and the research progress of circRNAs involved in normal development of skeletal muscle and regulation of skeletal muscle disease, in order to provide a reference to further study of the genetic mechanisms of circRNAs in the regulation of skeletal muscle development.

Key words: circRNA, skeletal muscle development, skeletal muscle diseases, RNA-seq